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Literature DB >> 8361637

Area-dependent changes in GABAergic function after acute and chronic cold stress.

G B Acosta¹, M E Otero Losada, M C Rubio.

Abstract

(1) The function of the gamma-aminobutyric acid (GABA)ergic system in certain areas of the rat brain was investigated after acute and chronic cold stress. (2) GABA concentration, [3H]GABA uptake and the activity of the synthesis enzyme glutamate decarboxylase (GAD) were measured. (3) Acute stress: (a) reduced GABA concentration in the corpus striatum (29%); (b) decreased GAD activity (under non-saturating substrate concentration) in the olfactory bulbs (24%); (c) diminished neuronal uptake of [3H]GABA in the frontal cerebral cortex (65%), hypothalamus (86%) and olfactory bulbs (82%). (4) Chronic stress: (a) reduced the endogenous levels of GABA in the frontal cerebral cortex (51%), hypothalamus (26%) and olfactory bulbs (15%); (b) decreased GAD activity in the corpus striatum (32%) and olfactory bulbs (34%); (c) decreased neuronal uptake of [3H]GABA in the hypothalamus (83%). (5) These findings suggest that compensatory changes may develop in the GABAergic system after chronic stress.

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Year: 1993 PMID： 8361637 DOI： 10.1016/0304-3940(93)90200-5

Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046

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Area-dependent changes in GABAergic function after acute and chronic cold stress.

1. Response to flumazenil in the late luteal phase and follicular phase of the menstrual cycle in healthy control females.

2. Restraint stress-induced alterations in the levels of biogenic amines, amino acids, and AChE activity in the hippocampus.

3. Prefrontal Cortex GABAergic Deficits and Circuit Dysfunction in the Pathophysiology and Treatment of Chronic Stress and Depression.

4. The response to postnatal stress: amino acids transporters and PKC activity.

Review 5. Neurosteroid biosynthesis down-regulation and changes in GABA_A receptor subunit composition: a biomarker axis in stress-induced cognitive and emotional impairment.

6. Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice.

7. Chronic cold exposure increases RGS7 expression and decreases alpha(2)-autoreceptor-mediated inhibition of noradrenergic locus coeruleus neurons.

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9. The reciprocal regulation of stress hormones and GABA(A) receptors.

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Review 5. Neurosteroid biosynthesis down-regulation and changes in GABAA receptor subunit composition: a biomarker axis in stress-induced cognitive and emotional impairment.

Review 8. The non-motor syndrome of primary dystonia: clinical and pathophysiological implications.

Review 10. Stress-induced plasticity of GABAergic inhibition.

Review 5. Neurosteroid biosynthesis down-regulation and changes in GABA_A receptor subunit composition: a biomarker axis in stress-induced cognitive and emotional impairment.