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Literature DB >> 836073

The effects of prostaglandins E1 and F2alpha on epidermal growth.

C B Bentley-Phillips, H Paulli-Jorgensen, R Marks.

Abstract

The effects of prostaglandins E1 and F2alpha (PGE1 and PGF2alpha) on the growth of guinea pig epidermis have been studied in vivo. The prostaglandins were injected intradermally into guinea pigs, and tritiated thymidine was injected intraperitoneally prior to sacrifice. The autoradiographic labelling indices (L.I.) were assessed and a significant increase was found 4 h after injection of PGE1 -an effect which lasted for up to 72 h. PGF2alpha injections had no significant effect on the L.I.

Entities: Chemical Species

Mesh：

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Year: 1977 PMID： 836073 DOI： 10.1007/BF00741838

Source DB: PubMed Journal: Arch Dermatol Res Impact factor: 3.017

9 in total

1. Simplified liquid emulsion radioautography.

Authors: D L JOFTES; S WARREN
Journal: J Biol Photogr Assoc Date: 1955-11

2. Prostaglandins and cyclic AMP in epidermis. Evidence for the independent action of prostaglandins and adrenaline on the adenyl cyclase system of pig and human epidermis, normal and psoriatic.

Authors: K Adachi; K Yoshikawa; K M Halprin; V Levine
Journal: Br J Dermatol Date: 1975-04 Impact factor: 9.302

6. In vitro analysis of the control of keratinocyte proliferation in human epidermis by physiologic and pharmacologic agents.

Authors: B A Flaxman; R A Harper
Journal: J Invest Dermatol Date: 1975-07 Impact factor: 8.551

7. Reduced epidermal cyclic AMP accumulation following prostaglandin stimulation: Its possible role in the pathophysiology of psoriasis.

Authors: K Aso; E K Orenberg; E M Farber
Journal: J Invest Dermatol Date: 1975-10 Impact factor: 8.551

8. Effects of specific prostaglandins on development of chick embryo skin and down feather organ, in vitro.

Authors: C W Kischer
Journal: Dev Biol Date: 1967-09 Impact factor: 3.582

Review 9. The role of adenosine 3',5'-cyclic monophosphate in the regulation of mammalian cell division.

Authors: C W Abell; T M Monahan
Journal: J Cell Biol Date: 1973-12 Impact factor: 10.539

9 in total

3 in total

The effects of prostaglandins E1 and F2alpha on epidermal growth.

1. Simplified liquid emulsion radioautography.

2. Prostaglandins and cyclic AMP in epidermis. Evidence for the independent action of prostaglandins and adrenaline on the adenyl cyclase system of pig and human epidermis, normal and psoriatic.

3. Prostaglandin and DNA synthesis in human skin: possible relationship to ultraviolet light effects.

4. Stimulation of DNA synthesis and mitotic activity of thymic lymphocytes by cyclic adenosine 3'5'-monophosphate.

5. Prostaglandin E1 effects on epidermal cell growth "in vitro".

6. In vitro analysis of the control of keratinocyte proliferation in human epidermis by physiologic and pharmacologic agents.

7. Reduced epidermal cyclic AMP accumulation following prostaglandin stimulation: Its possible role in the pathophysiology of psoriasis.

8. Effects of specific prostaglandins on development of chick embryo skin and down feather organ, in vitro.

Review 9. The role of adenosine 3',5'-cyclic monophosphate in the regulation of mammalian cell division.

1. Factors responsible for dermally induced epidermal hyperplasia.

2. Modulation of keratinocyte proliferation in vitro by endogenous prostaglandin synthesis.

3. Transepidermal elimination: studies with an animal model.