Literature DB >> 8360331

Trafficking of activated cytotoxic T lymphocytes into the central nervous system: use of a transgenic model.

M B Oldstone1, P J Southern.   

Abstract

We have used cell or tissue-specific promoters to express lymphocytic choriomeningitis virus (LCMV) proteins in selected cells in independent lines of transgenic mice. Upon adoptive transfers into these mice, MHC-restricted LCMV-specific cytotoxic T lymphocytes homed specifically to either the choroid plexus (SV40 promoter) or beta cells of the islets of Langerhans (rat insulin promoter). The availability of promoters specific for neurons, oligodendrocytes and astrocytes makes this approach compelling for evaluating T cell trafficking into the CNS and for analyzing antigen presentation in vivo in the CNS.

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Year:  1993        PMID： 8360331      PMCID： PMC7119476          DOI： 10.1016/0165-5728(93)90230-v

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  29 in total

1.  Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule.

Authors:  Y Yanagi; A Tishon; H Lewicki; B A Cubitt; M B Oldstone
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103

2.  Design of high-affinity major histocompatibility complex-specific antagonist peptides that inhibit cytotoxic T-lymphocyte activity: implications for control of viral disease.

Authors:  J E Gairin; M B Oldstone
Journal:  J Virol       Date:  1992-11       Impact factor: 5.103

3.  Vaccination and protection from a lethal viral infection: identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope.

Authors:  L S Klavinskis; J L Whitton; E Joly; M B Oldstone
Journal:  Virology       Date:  1990-10       Impact factor: 3.616

4.  Isolation of an endogenously processed immunodominant viral peptide from the class I H-2Kb molecule.

Authors:  G M Van Bleek; S G Nathenson
Journal:  Nature       Date:  1990-11-15       Impact factor: 49.962

5.  The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides.

Authors:  A R Townsend; J Rothbard; F M Gotch; G Bahadur; D Wraith; A J McMichael
Journal:  Cell       Date:  1986-03-28       Impact factor: 41.582

6.  Efficiency and effectiveness of cloned virus-specific cytotoxic T lymphocytes in vivo.

Authors:  L S Klavinskis; A Tishon; M B Oldstone
Journal:  J Immunol       Date:  1989-09-15       Impact factor: 5.422

7.  Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system.

Authors:  M B Oldstone; P Blount; P J Southern; P W Lampert
Journal:  Nature       Date:  1986 May 15-21       Impact factor: 49.962

8.  Rapid activation of astrocyte-specific expression of GFAP-lacZ transgene by focal injury.

Authors:  L Mucke; M B Oldstone; J C Morris; M I Nerenberg
Journal:  New Biol       Date:  1991-05

9.  JC virus and simian virus 40 enhancers and transforming proteins: role in determining tissue specificity and pathogenicity in transgenic mice.

Authors:  L Feigenbaum; S H Hinrichs; G Jay
Journal:  J Virol       Date:  1992-02       Impact factor: 5.103

10.  Adoptive transfer of EAE-like lesions from rats with coronavirus-induced demyelinating encephalomyelitis.

Authors:  R Watanabe; H Wege; V ter Meulen
Journal:  Nature       Date:  1983 Sep 8-14       Impact factor: 49.962
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  6 in total

Review 1.  Enhanced prospects for drug delivery and brain targeting by the choroid plexus-CSF route.

Authors:  Conrad E Johanson; John A Duncan; Edward G Stopa; Andrew Baird
Journal:  Pharm Res       Date:  2005-07-22       Impact factor: 4.200

Review 2.  Novel approaches to treating leptomeningeal metastases.

Authors:  Jai Grewal; Marlon Garzo Saria; Santosh Kesari
Journal:  J Neurooncol       Date:  2011-08-28       Impact factor: 4.130

3.  Selective modification of antigen-specific T cells by RNA electroporation.

Authors:  Duane A Mitchell; Isaac Karikari; Xiuyu Cui; Weihua Xie; Robert Schmittling; John H Sampson
Journal:  Hum Gene Ther       Date:  2008-05       Impact factor: 5.695

4.  CNS recruitment of CD8+ T lymphocytes specific for a peripheral virus infection triggers neuropathogenesis during polymicrobial challenge.

Authors:  Christine M Matullo; Kevin J O'Regan; Mark Curtis; Glenn F Rall
Journal:  PLoS Pathog       Date:  2011-12-22       Impact factor: 6.823

5.  Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo.

Authors:  G F Rall; L Mucke; M B Oldstone
Journal:  J Exp Med       Date:  1995-11-01       Impact factor: 14.307

6.  A transgenic mouse model to assess the interaction of cytotoxic T lymphocytes with virally infected, class I MHC-expressing astrocytes.

Authors:  G F Rall; L Mucke; M Nerenberg; M B Oldstone
Journal:  J Neuroimmunol       Date:  1994-06       Impact factor: 3.478
  6 in total

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