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Literature DB >> 8360144

Cell cycle-dependent suppressive effect of histone H1 on mitosis-specific H3 phosphorylation.

Abstract

To analyze the mechanism by which histone H3 phosphorylation occurs specifically during mitosis, the effect of H1 on mitosis-specific H3 phosphorylation (Ser-10) was investigated in nucleosomes. H1 interaction with H1-depleted nucleosomes suppressed H3 phosphorylation including Ser-10 by approximately 50%. However, H1 interaction with DNA-free histone octamers failed to suppress H3 phosphorylation. The extent of suppression of H3 phosphorylation in nucleosomes with H1 prepared from synchronized HeLa cells was cell cycle-dependent. Binding with a highly phosphorylated mitotic H1 produced the least suppression of H3 phosphorylation, whereas binding with a lower H1 phosphorylation from G1 phase resulted in the greatest suppression. The results suggest that 1) mitotic H3 phosphorylation is suppressed with a lower level of H1 phosphorylation during interphase and 2) highly phosphorylated H1 during mitosis partially releases the suppression of mitotic H3 phosphorylation.

Entities: Chemical Gene

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Year: 1993 PMID： 8360144

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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Cited

15 in total

1. Transplantation dose alters the dynamics of human neural stem cell engraftment, proliferation and migration after spinal cord injury.

Authors: Katja M Piltti; Sabrina N Avakian; Gabriella M Funes; Antoinette Hu; Nobuko Uchida; Aileen J Anderson; Brian J Cummings
Journal: Stem Cell Res Date: 2015-07-26 Impact factor: 2.020

9. Chromosome condensation induced by fostriecin does not require p34cdc2 kinase activity and histone H1 hyperphosphorylation, but is associated with enhanced histone H2A and H3 phosphorylation.

Authors: X W Guo; J P Th'ng; R A Swank; H J Anderson; C Tudan; E M Bradbury; M Roberge
Journal: EMBO J Date: 1995-03-01 Impact factor: 11.598

10. Regulation of the phosphorylation of human pharyngeal cell proteins by group A streptococcal surface dehydrogenase: signal transduction between streptococci and pharyngeal cells.

Authors: V Pancholi; V A Fischetti
Journal: J Exp Med Date: 1997-11-17 Impact factor: 14.307

Cell cycle-dependent suppressive effect of histone H1 on mitosis-specific H3 phosphorylation.

1. Transplantation dose alters the dynamics of human neural stem cell engraftment, proliferation and migration after spinal cord injury.

2. Effects of cell cycle dependent histone H1 phosphorylation on chromatin structure and chromatin replication.

3. Dual Immunohistochemical Detection of Mitoses in Melanoma.

4. Mitotic Index is an Independent Predictor of Recurrence-Free Survival in Meningioma.

5. Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model.

6. A proposal for a coherent mammalian histone H1 nomenclature correlated with amino acid sequences.

7. Lack of a p21waf1/cip -dependent G1/S checkpoint in neural stem and progenitor cells after DNA damage in vivo.

8. In vivo importance of homologous recombination DNA repair for mouse neural stem and progenitor cells.

9. Chromosome condensation induced by fostriecin does not require p34cdc2 kinase activity and histone H1 hyperphosphorylation, but is associated with enhanced histone H2A and H3 phosphorylation.

10. Regulation of the phosphorylation of human pharyngeal cell proteins by group A streptococcal surface dehydrogenase: signal transduction between streptococci and pharyngeal cells.