Literature DB >> 8360104

UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties.

M Ueki1, K Ueno, S Miyadoh, K Abe, K Shibata, M Taniguchi, S Oi.   

Abstract

A new benzoxazole, UK-1, was isolated from the mycelial cake of an actinomycete strain 517-02. Based on morphological, cultural and physiological characteristics, strain 517-02 was seemed to be a close relative of Streptomyces morookaense. UK-1 showed potent cytotoxic activity against B16, HeLa and P388 cells and did not show any antimicrobial activity.

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Year:  1993        PMID： 8360104     DOI： 10.7164/antibiotics.46.1089

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

1.  Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1.

Authors:  Mireya L McKee; Sean M Kerwin
Journal:  Bioorg Med Chem       Date:  2007-11-12       Impact factor: 3.641

2.  UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication.

Authors:  Dawn N Ward; Daniel C Talley; Mrinalini Tavag; Samrawit Menji; Paul Schaughency; Andrea Baier; Paul J Smith
Journal:  Bioorg Med Chem Lett       Date:  2013-12-09       Impact factor: 2.823

3.  Evaluation of metal-mediated DNA binding of benzoxazole ligands by electrospray ionization mass spectrometry.

Authors:  Carolyn L Mazzitelli; Mireya Rodriguez; Sean M Kerwin; Jennifer S Brodbelt
Journal:  J Am Soc Mass Spectrom       Date:  2007-05-23       Impact factor: 3.109

4.  Caboxamycin biosynthesis pathway and identification of novel benzoxazoles produced by cross-talk in Streptomyces sp. NTK 937.

Authors:  Armando A Losada; Carolina Cano-Prieto; Raúl García-Salcedo; Alfredo F Braña; Carmen Méndez; José A Salas; Carlos Olano
Journal:  Microb Biotechnol       Date:  2017-04-18       Impact factor: 5.813

5.  Draft Genome Sequence of Marine Actinomycete Streptomyces sp. Strain NTK 937, Producer of the Benzoxazole Antibiotic Caboxamycin.

Authors:  Carlos Olano; Carolina Cano-Prieto; Armando A Losada; Alan T Bull; Michael Goodfellow; Hans-Peter Fiedler; Carmen Méndez; José A Salas
Journal:  Genome Announc       Date:  2014-07-03

6.  Biological activity of 3-(2-benzoxazol-5-yl)alanine derivatives.

Authors:  Katarzyna Guzow; Ewa Mulkiewicz; Michał Obuchowski; Wiesław Wiczk
Journal:  Amino Acids       Date:  2021-07-08       Impact factor: 3.520
  6 in total

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