Literature DB >> 8360099

R1128 substances, novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces. I. Taxonomy, fermentation, isolation and biological properties.

Y Hori1, Y Abe, M Ezaki, T Goto, M Okuhara, M Kohsaka.   

Abstract

New non-steroidal estrogen-receptor antagonists, R1128 A, B, C and D, were isolated from the cultured broth of Streptomyces sp. No. 1128 by solvent extraction, silica gel chromatography, reverse phase chromatography and preparative HPLC. These compounds inhibited estrogen binding to its receptor. The IC50 values of R1128 A, B, C and D for partially purified rat uterine cytosol receptor were 1.1 x 10(-7) M, 1.2 x 10(-7) M, 2.6 x 10(-7) M and 2.7 x 10(-7) M, respectively.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8360099     DOI： 10.7164/antibiotics.46.1055

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

1.  New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883.

Authors:  Zhikai Guo; Guohui Pan; Zhengren Xu; Dong Yang; Xiangcheng Zhu; Yong Huang; Li-Xing Zhao; Yi Jiang; Yanwen Duan; Ben Shen
Journal:  J Antibiot (Tokyo)       Date:  2016-10-12       Impact factor: 2.649

2.  Identification and characterization of a novel estrogenic ligand actinopolymorphol A.

Authors:  Emily Powell; Sheng-Xiong Huang; Yong Xu; Scott R Rajski; Yidan Wang; Noel Peters; Song Guo; H Eric Xu; F Michael Hoffmann; Ben Shen; Wei Xu
Journal:  Biochem Pharmacol       Date:  2010-06-25       Impact factor: 5.858

3.  Engineered biosynthesis of aklanonic acid analogues.

Authors:  Taek Soon Lee; Chaitan Khosla; Yi Tang
Journal:  J Am Chem Soc       Date:  2005-09-07       Impact factor: 15.419

Review 4.  Biosynthesis of Oxytetracycline by Streptomyces rimosus:
Past, Present and Future Directions in the Development
of Tetracycline Antibiotics.

Authors:  Hrvoje Petković; Tadeja Lukežič; Jagoda Šušković
Journal:  Food Technol Biotechnol       Date:  2017-03       Impact factor: 3.918

Review 5.  3-Ketoacyl-ACP synthase (KAS) III homologues and their roles in natural product biosynthesis.

Authors:  Risa Nofiani; Benjamin Philmus; Yosi Nindita; Taifo Mahmud
Journal:  Medchemcomm       Date:  2019-04-29       Impact factor: 3.597

6.  Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases.

Authors:  Yi Tang; Taek Soon Lee; Chaitan Khosla
Journal:  PLoS Biol       Date:  2004-02-17       Impact factor: 8.029
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.