Literature DB >> 8359922

Clostridium difficile toxin A elicits Ca(2+)-independent cytotoxic effects in cultured normal rat intestinal crypt cells.

C Fiorentini1, G Donelli, P Nicotera, M Thelestam.   

Abstract

In rat intestinal crypt cells, Clostridium difficile toxin A induces (i) early cytoskeletal alterations involving the whole population and (ii) late effects in 30 to 40% of the cells, consisting mainly of surface blebbing and nuclear fragmentation. All these effects were Ca2+ independent and were not abolished by protein synthesis inhibitors.

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Year:  1993        PMID： 8359922      PMCID： PMC281105          DOI： 10.1128/iai.61.9.3988-3993.1993

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  25 in total

1.  Effects of Clostridium difficile toxins A and B on cytoskeleton organization in HEp-2 cells: a comparative morphological study.

Authors:  C Fiorentini; G Arancia; S Paradisi; G Donelli; M Giuliano; F Piemonte; P Mastrantonio
Journal:  Toxicon       Date:  1989       Impact factor: 3.033

2.  Interaction of Clostridium difficile toxin A with cultured cells: cytoskeletal changes and nuclear polarization.

Authors:  C Fiorentini; W Malorni; S Paradisi; M Giuliano; P Mastrantonio; G Donelli
Journal:  Infect Immun       Date:  1990-07       Impact factor: 3.441

3.  A23187: a divalent cation ionophore.

Authors:  P W Reed; H A Lardy
Journal:  J Biol Chem       Date:  1972-11-10       Impact factor: 5.157

4.  Intoxication of cultured human lung fibroblasts with Clostridium difficile toxin.

Authors:  I Florin; M Thelestam
Journal:  Infect Immun       Date:  1981-07       Impact factor: 3.441

Review 5.  Clostridium difficile: its disease and toxins.

Authors:  D M Lyerly; H C Krivan; T D Wilkins
Journal:  Clin Microbiol Rev       Date:  1988-01       Impact factor: 26.132

6.  Cellular internalisation of Clostridium difficile toxin A.

Authors:  B Henriques; I Florin; M Thelestam
Journal:  Microb Pathog       Date:  1987-06       Impact factor: 3.738

Review 7.  Calcium channels: molecular pharmacology, structure and regulation.

Authors:  M M Hosey; M Lazdunski
Journal:  J Membr Biol       Date:  1988-09       Impact factor: 1.843

8.  Cytosolic-free Ca2+ and cell killing in hepatoma 1c1c7 cells exposed to chemical anoxia.

Authors:  P Nicotera; H Thor; S Orrenius
Journal:  FASEB J       Date:  1989-01       Impact factor: 5.191

9.  Surface blebbing and cytoskeletal changes induced in vitro by toxin B from Clostridium difficile: an immunochemical and ultrastructural study.

Authors:  W Malorni; C Fiorentini; S Paradisi; M Giuliano; P Mastrantonio; G Donelli
Journal:  Exp Mol Pathol       Date:  1990-06       Impact factor: 3.362

10.  Clostridium difficile toxin A stimulates intracellular calcium release and chemotactic response in human granulocytes.

Authors:  C Pothoulakis; R Sullivan; D A Melnick; G Triadafilopoulos; A S Gadenne; T Meshulam; J T LaMont
Journal:  J Clin Invest       Date:  1988-06       Impact factor: 14.808
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  7 in total

1.  Vibrio parahaemolyticus thermostable direct hemolysin modulates cytoskeletal organization and calcium homeostasis in intestinal cultured cells.

Authors:  A Fabbri; L Falzano; C Frank; G Donelli; P Matarrese; F Raimondi; A Fasano; C Fiorentini
Journal:  Infect Immun       Date:  1999-03       Impact factor: 3.441

2.  Regulation of Apoptosis by Gram-Positive Bacteria: Mechanistic Diversity and Consequences for Immunity.

Authors:  Glen C Ulett; Elisabeth E Adderson
Journal:  Curr Immunol Rev       Date:  2006-05

Review 3.  Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion.

Authors:  C L Sears; J B Kaper
Journal:  Microbiol Rev       Date:  1996-03

4.  Clostridium difficile toxin B induces apoptosis in intestinal cultured cells.

Authors:  C Fiorentini; A Fabbri; L Falzano; A Fattorossi; P Matarrese; R Rivabene; G Donelli
Journal:  Infect Immun       Date:  1998-06       Impact factor: 3.441

Review 5.  Clostridium difficile infection: molecular pathogenesis and novel therapeutics.

Authors:  Ardeshir Rineh; Michael J Kelso; Fatma Vatansever; George P Tegos; Michael R Hamblin
Journal:  Expert Rev Anti Infect Ther       Date:  2014-01       Impact factor: 5.091

6.  Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebbing in HT-29 cells.

Authors:  G Donelli; A Fabbri; C Fiorentini
Journal:  Infect Immun       Date:  1996-01       Impact factor: 3.441

7.  Human intestinal enteroids as a model of Clostridioides difficile-induced enteritis.

Authors:  Melinda A Engevik; Heather A Danhof; Alexandra L Chang-Graham; Jennifer K Spinler; Kristen A Engevik; Beatrice Herrmann; Bradley T Endres; Kevin W Garey; Joseph M Hyser; Robert A Britton; James Versalovic
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2020-03-30       Impact factor: 4.052
  7 in total

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