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Literature DB >> 8359659

HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis.

Abstract

The overrepresentation of particular HLA alleles in patients with celiac disease was first noted two decades ago. Several lines of evidence obtained during the last years strongly suggest that a particular HLA-DQ heterodimer, encoded by the DQA1*0501 and DQB1*0201 genes in cis or trans configuration, confers the primary disease susceptibility. This paper reviews the evidence behind this concept and discusses how this particular DQ molecule may be involved in the pathogenesis.

Entities: Gene Species

Mesh：

Year: 1993 PMID： 8359659 DOI： 10.1016/0016-5085(93)90912-v

Source DB: PubMed Journal: Gastroenterology ISSN： 0016-5085 Impact factor: 22.682

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Cited

98 in total

1. Relative power of linkage and transmission disequilibrium test strategies to detect non-HLA linked coeliac disease susceptibility genes.

Authors: S Bevan; S Popat; R S Houlston
Journal: Gut Date: 1999-11 Impact factor: 23.059

2. Contribution of the MHC region to the familial risk of coeliac disease.

Authors: S Bevan; S Popat; C P Braegger; A Busch; D O'Donoghue; K Falth-Magnusson; A Ferguson; A Godkin; L Hogberg; G Holmes; K B Hosie; P D Howdle; H Jenkins; D Jewell; S Johnston; N P Kennedy; G Kerr; P Kumar; R F Logan; A H Love; M Marsh; C J Mulder; K Sjoberg; L Stenhammer; J Walker-Smith; A M Marossy; R S Houlston
Journal: J Med Genet Date: 1999-09 Impact factor: 6.318

HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis.

1. Relative power of linkage and transmission disequilibrium test strategies to detect non-HLA linked coeliac disease susceptibility genes.

2. Contribution of the MHC region to the familial risk of coeliac disease.

Review 3. Pathogenesis of coeliac disease: implications for treatment.

Review 4. Genetic factors underlying gluten-sensitive enteropathy.

5. Interplay between genetics and the environment in the development of celiac disease: perspectives for a healthy life.

Review 6. Celiac disease: diagnostic criteria in progress.

7. Presentations of adult celiac disease in a nationwide patient support group.

Review 8. Genetic susceptibility in type 1 diabetes and its associated autoimmune disorders.

Review 9. Association of primary sclerosing cholangitis and celiac disease: a case report and review of the literature.

10. Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease.