| Literature DB >> 8359557 |
T Kitajima1, T Yamaguchi, K Tani, Y Kubota, M Okuhira, K Inoue, H Yamada.
Abstract
The current study was designed to investigate the role of two potent vasoactive substances, endothelin (ET) and platelet-activating factor (PAF), in the pathogenesis of indomethacin-induced gastric lesions in rats. Treatment with anti-ET antibody before indomethacin administration resulted in a significant decline in the total length of the lesions as determined by gross evaluation. In contrast, CV-6209, a specific PAF antagonist, had no effect on the total length of the lesions. The results strongly suggest the incorporation of endogenous ET in the mechanism of gastric damage after indomethacin administration.Entities:
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Year: 1993 PMID： 8359557 DOI： 10.1159/000201030
Source DB: PubMed Journal: Digestion ISSN： 0012-2823 Impact factor: 3.216