Literature DB >> 8358624

A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred.

F Tagliavini1, G Giaccone, F Prelli, L Verga, M Porro, J Q Trojanowski, M R Farlow, B Frangione, B Ghetti, O Bugiani.   

Abstract

Gerstmann-Sträussler-Scheinker disease in the Indiana kindred is pathologically characterized by prion protein amyloid deposits and neurofibrillary tangles (NFT) with paired helical filaments (PHF). Using antibodies to various domains of the tau molecule, we investigated the composition of PHF in this family by immunocytochemistry and immunoblot analysis. The results indicate that A68 is a component of NFT in this family as it is in Alzheimer's disease, and suggest that post-translational modifications of tau leading to formation of A68 are not unique to Alzheimer's disease.

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Year:  1993        PMID： 8358624     DOI： 10.1016/0006-8993(93)90226-d

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  13 in total

1.  Squirrel monkeys (Saimiri sciureus) infected with the agent of bovine spongiform encephalopathy develop tau pathology.

Authors:  P Piccardo; J Cervenak; O Yakovleva; L Gregori; K Pomeroy; A Cook; F S Muhammad; T Seuberlich; L Cervenakova; D M Asher
Journal:  J Comp Pathol       Date:  2011-10-20       Impact factor: 1.311

2.  Complex proteinopathy with accumulations of prion protein, hyperphosphorylated tau, α-synuclein and ubiquitin in experimental bovine spongiform encephalopathy of monkeys.

Authors:  Pedro Piccardo; Juraj Cervenak; Ming Bu; Lindsay Miller; David M Asher
Journal:  J Gen Virol       Date:  2014-04-25       Impact factor: 3.891

3.  Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype.

Authors:  Suman Jayadev; David Nochlin; Parvoneh Poorkaj; Ellen J Steinbart; James A Mastrianni; Thomas J Montine; Bernardino Ghetti; Gerard D Schellenberg; Thomas D Bird; James B Leverenz
Journal:  Ann Neurol       Date:  2011-03-17       Impact factor: 10.422

4.  Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments.

Authors:  M G Spillantini; M Goedert; R A Crowther; J R Murrell; M R Farlow; B Ghetti
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

Review 5.  Alzheimer's disease and prion proteins: a meeting made in muscle.

Authors:  P Gambetti; G Perry
Journal:  Am J Pathol       Date:  1994-12       Impact factor: 4.307

6.  Altered toxicity of the prion protein peptide PrP106-126 carrying the Ala(117)-->Val mutation.

Authors:  D R Brown
Journal:  Biochem J       Date:  2000-03-15       Impact factor: 3.857

7.  Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro.

Authors:  F Tagliavini; F Prelli; L Verga; G Giaccone; R Sarma; P Gorevic; B Ghetti; F Passerini; E Ghibaudi; G Forloni
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-15       Impact factor: 11.205

8.  Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease.

Authors:  Peter T Nelson; Erin L Abner; Frederick A Schmitt; Richard J Kryscio; Gregory A Jicha; Karen Santacruz; Charles D Smith; Ela Patel; William R Markesbery
Journal:  J Neuropathol Exp Neurol       Date:  2009-07       Impact factor: 3.685

9.  beta PP and Tau interaction. A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease.

Authors:  G Giaccone; B Pedrotti; A Migheli; L Verga; J Perez; G Racagni; M A Smith; G Perry; L De Gioia; C Selvaggini; M Salmona; J Ghiso; B Frangione; K Islam; O Bugiani; F Tagliavini
Journal:  Am J Pathol       Date:  1996-01       Impact factor: 4.307

Review 10.  Familial Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles.

Authors:  B Ghetti; F Tagliavini; G Giaccone; O Bugiani; B Frangione; M R Farlow; S R Dlouhy
Journal:  Mol Neurobiol       Date:  1994-02       Impact factor: 5.590
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