Literature DB >> 8358531

Peripheral endotoxin induces hypothalamic immunoreactive interleukin-1 beta in the rat.

E W Hillhouse1, K Mosley.   

Abstract

Interleukin-1 (IL-1) is a polypeptide produced by a variety of cells and contributes to the general host response to inflammation. It displays a wide spectrum of inflammatory, metabolic, physiological, haematopoietic and immunological activities. Brain cells, including neurones, microglia, endothelial cells and astrocytes can all produce IL-1 beta in response to various physiological and pathological stimuli. In this report we show that peripherally administered endotoxin stimulates the appearance of immunoreactive IL-1 beta (IL-1 beta) in the rat hypothalamus as measured by an ultrasensitive, highly specific enzyme amplified immunometric assay for rat IL-1 beta.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8358531      PMCID： PMC2175692          DOI： 10.1111/j.1476-5381.1993.tb13567.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness?

Authors:  A M van Dam; M Brouns; S Louisse; F Berkenbosch
Journal:  Brain Res       Date:  1992-08-21       Impact factor: 3.252

2.  Interleukin-1 beta stimulates somatostatin biosynthesis in primary cultures of fetal rat brain.

Authors:  D E Scarborough; S L Lee; C A Dinarello; S Reichlin
Journal:  Endocrinology       Date:  1989-01       Impact factor: 4.736

Review 3.  Functions and mechanisms of interleukin 1 in the brain.

Authors:  N J Rothwell
Journal:  Trends Pharmacol Sci       Date:  1991-11       Impact factor: 14.819

4.  Brain interleukin 1 gene expression induced by peripheral lipopolysaccharide administration.

Authors:  E Ban; F Haour; R Lenstra
Journal:  Cytokine       Date:  1992-01       Impact factor: 3.861

Review 5.  Fever: role of pyrogens and cryogens.

Authors:  M J Kluger
Journal:  Physiol Rev       Date:  1991-01       Impact factor: 37.312

6.  Interleukin-1 beta production in vivo and in vitro in rats and mice measured using specific immunoradiometric assays.

Authors:  A F Bristow; K Mosley; S Poole
Journal:  J Mol Endocrinol       Date:  1991-08       Impact factor: 5.098

7.  Involvement of organum vasculosum of lamina terminalis and preoptic area in interleukin 1 beta-induced ACTH release.

Authors:  G Katsuura; A Arimura; K Koves; P E Gottschall
Journal:  Am J Physiol       Date:  1990-01
  7 in total
  10 in total

Review 1.  Hypothalamic mechanisms in cachexia.

Authors:  Aaron J Grossberg; Jarrad M Scarlett; Daniel L Marks
Journal:  Physiol Behav       Date:  2010-03-25

2.  Deletion of the ventral noradrenergic bundle obliterates the early ACTH response after systemic LPS, independently from the plasma IL-1β surge.

Authors:  L Givalois; S Gaillet; M Mekaouche; C Ixart; A F Bristow; P Siaud; A Szafarczyk; F Malaval; I Assenmacher; G Barbanel
Journal:  Endocrine       Date:  1995-07       Impact factor: 3.633

Review 3.  Exposure to acute stress induces brain interleukin-1beta protein in the rat.

Authors:  K T Nguyen; T Deak; S M Owens; T Kohno; M Fleshner; L R Watkins; S F Maier
Journal:  J Neurosci       Date:  1998-03-15       Impact factor: 6.167

Review 4.  Interleukin-1β with learning and memory.

Authors:  Zhen-Bo Huang; Guo-Qing Sheng
Journal:  Neurosci Bull       Date:  2010-12       Impact factor: 5.203

Review 5.  Role of interleukin-1 in stress responses. A putative neurotransmitter.

Authors:  F Shintani; T Nakaki; S Kanba; R Kato; M Asai
Journal:  Mol Neurobiol       Date:  1995-02       Impact factor: 5.590

6.  Central interleukin-1 beta stimulation of vasopressin release into the rat brain: activation of an antipyretic pathway.

Authors:  M F Wilkinson; T F Horn; N W Kasting; Q J Pittman
Journal:  J Physiol       Date:  1994-12-15       Impact factor: 5.182

7.  Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130.

Authors:  Aaron J Grossberg; Jarrad M Scarlett; XinXia Zhu; Darren D Bowe; Ayesha K Batra; Theodore P Braun; Daniel L Marks
Journal:  Endocrinology       Date:  2009-12-16       Impact factor: 4.736

8.  Repeated lipopolysaccharide (LPS) or cytokine treatments sensitize ethanol withdrawal-induced anxiety-like behavior.

Authors:  George R Breese; Darin J Knapp; David H Overstreet; Montserrat Navarro; Tiffany A Wills; Robert A Angel
Journal:  Neuropsychopharmacology       Date:  2007-06-06       Impact factor: 7.853

9.  Maternal immune activation by poly I:C induces expression of cytokines IL-1β and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain.

Authors:  Géraldine Arrode-Brusés; Juan L Brusés
Journal:  J Neuroinflammation       Date:  2012-04-30       Impact factor: 8.322

10.  Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion.

Authors:  R Horai; M Asano; K Sudo; H Kanuka; M Suzuki; M Nishihara; M Takahashi; Y Iwakura
Journal:  J Exp Med       Date:  1998-05-04       Impact factor: 14.307
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.