Literature DB >> 8358401

Application of microwave heating to the synthesis of [18F]fluoromisonidazole.

T J McCarthy1, C S Dence, M J Welch.   

Abstract

A modified synthesis of [18F]fluoromisonidazole is reported which makes use of microwave heating to reduce the synthesis time to ca 70 min from EOB. A remote system for column purification, concentration and delivery to an HPLC syringe, which reduces the total absorbed dose to the operator, is also described.

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Year:  1993        PMID： 8358401     DOI： 10.1016/0969-8043(93)90118-t

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  3 in total

1.  Microwave-assisted radiosynthesis of [18F]fluorinated fatty acid analogs.

Authors:  Anthony P Belanger; Mukesh K Pandey; Timothy R DeGrado
Journal:  Nucl Med Biol       Date:  2010-12-03       Impact factor: 2.408

2.  Autoradiographic and small-animal PET comparisons between (18)F-FMISO, (18)F-FDG, (18)F-FLT and the hypoxic selective (64)Cu-ATSM in a rodent model of cancer.

Authors:  Carmen S Dence; Datta E Ponde; Michael J Welch; Jason S Lewis
Journal:  Nucl Med Biol       Date:  2008-08       Impact factor: 2.408

3.  Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin.

Authors:  Takayuki Ohkubo; Yusuke Kurihara; Masanao Ogawa; Nobuki Nengaki; Masayuki Fujinaga; Wakana Mori; Katsushi Kumata; Masayuki Hanyu; Kenji Furutsuka; Hiroki Hashimoto; Kazunori Kawamura; Ming-Rong Zhang
Journal:  EJNMMI Radiopharm Chem       Date:  2021-07-10
  3 in total

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