Literature DB >> 8358353

Pharmacokinetics and biodistribution of radiolabeled avidin, streptavidin and biotin.

S F Rosebrough1.   

Abstract

The extraordinary high affinity of avidin and streptavidin for biotin may be exploited in a two-step approach for delivering radiolabeled biotin derivatives suitable for imaging and therapy to target-bound streptavidin or avidin conjugated monoclonal antibodies (MAbs). The in vivo pharmacokinetics and biodistribution of radiolabeled avidin, streptavidin (SA) and DTPA-biocytinamide (DTPA-biotin) were studied in the rabbit and dog. SA circulated in the blood similar to other 60 kDa proteins, avidin cleared immediately and DTPA-biotin exhibited plasma clearance by glomerular filtration.

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Year:  1993        PMID： 8358353     DOI： 10.1016/0969-8051(93)90037-u

Source DB:  PubMed          Journal:  Nucl Med Biol        ISSN： 0969-8051            Impact factor:   2.408


  17 in total

1.  Pretargeted radioimmunotherapy using genetically engineered antibody-streptavidin fusion proteins for treatment of non-hodgkin lymphoma.

Authors:  Steven I Park; Jaideep Shenoi; Shani M Frayo; Donald K Hamlin; Yukang Lin; D Scott Wilbur; Patrick S Stayton; Nural Orgun; Mark Hylarides; Franz Buchegger; Aimee L Kenoyer; Amanda Axtman; Ajay K Gopal; Damian J Green; John M Pagel; Oliver W Press
Journal:  Clin Cancer Res       Date:  2011-10-05       Impact factor: 12.531

Review 2.  Radioimmunotherapy of human tumours.

Authors:  Steven M Larson; Jorge A Carrasquillo; Nai-Kong V Cheung; Oliver W Press
Journal:  Nat Rev Cancer       Date:  2015-06       Impact factor: 60.716

3.  Quantitative Correlation of in Vivo Properties with in Vitro Assay Results: The in Vitro Binding of a Biotin-DNA Analogue Modifier with Streptavidin Predicts the in Vivo Avidin-Induced Clearability of the Analogue-Modified Antibody.

Authors:  Shuping Dou; John Virostko; Dale L Greiner; Alvin C Powers; Guozheng Liu
Journal:  Mol Pharm       Date:  2015-07-08       Impact factor: 4.939

Review 4.  Targeting erbB receptors.

Authors:  Zheng Cai; Hongtao Zhang; Jing Liu; Alan Berezov; Ramachandran Murali; Qiang Wang; Mark I Greene
Journal:  Semin Cell Dev Biol       Date:  2010-09-17       Impact factor: 7.727

5.  Tumor-specific detection of an optically targeted antibody combined with a quencher-conjugated neutravidin "quencher-chaser": a dual "quench and chase" strategy to improve target to nontarget ratios for molecular imaging of cancer.

Authors:  Mikako Ogawa; Nobuyuki Kosaka; Peter L Choyke; Hisataka Kobayashi
Journal:  Bioconjug Chem       Date:  2009-01       Impact factor: 4.774

6.  OXavidin for tissue targeting biotinylated therapeutics.

Authors:  Rita De Santis; Claudio Albertoni; Antonio Rosi; Barbara Leoni; Fiorella Petronzelli; Valeria D'Alessio; Eleonora Nucera; Giovanni Salvatori; Giovanni Paganelli; Antonio Verdoliva; Paolo Carminati; Carlo Antonio Nuzzolo
Journal:  J Biomed Biotechnol       Date:  2010-01-10

7.  Characterization of poultry egg-white avidins and their potential as a tool in pretargeting cancer treatment.

Authors:  Vesa P Hytönen; Olli H Laitinen; Alessandro Grapputo; Anu Kettunen; Janne Savolainen; Nisse Kalkkinen; Ari T Marttila; Henri R Nordlund; Thomas K M Nyholm; Giovanni Paganelli; Markku S Kulomaa
Journal:  Biochem J       Date:  2003-05-15       Impact factor: 3.857

8.  A comparative analysis of conventional and pretargeted radioimmunotherapy of B-cell lymphomas by targeting CD20, CD22, and HLA-DR singly and in combinations.

Authors:  John M Pagel; Nural Orgun; Donald K Hamlin; D Scott Wilbur; Theodore A Gooley; Ajay K Gopal; Steven I Park; Damian J Green; Yukang Lin; Oliver W Press
Journal:  Blood       Date:  2009-01-05       Impact factor: 22.113

9.  Development of streptavidin-based nanocomplex for siRNA delivery.

Authors:  Ravi S Shukla; Wanyi Tai; Rubi Mahato; Wei Jin; Kun Cheng
Journal:  Mol Pharm       Date:  2013-10-25       Impact factor: 4.939

10.  Structural and functional characteristics of xenavidin, the first frog avidin from Xenopus tropicalis.

Authors:  Juha A E Määttä; Satu H Helppolainen; Vesa P Hytönen; Mark S Johnson; Markku S Kulomaa; Tomi T Airenne; Henri R Nordlund
Journal:  BMC Struct Biol       Date:  2009-09-29
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