Literature DB >> 8356576

Human placental cholesterol side-chain cleavage: enzymatic synthesis of (22R)-20 alpha,22-dihydroxycholesterol.

R C Tuckey1, K J Cameron.   

Abstract

(22R)-20 alpha,22-Dihydroxycholesterol is the second intermediate in the conversion of cholesterol to pregnenolone by cytochrome P450scc in steroidogenic tissues. We report a rapid method for the enzymatic synthesis of (22R)-20 alpha,22-dihydroxycholesterol from (22R)-22-hydroxycholesterol using mitochondria from the human placenta.

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Year:  1993        PMID： 8356576     DOI： 10.1016/0039-128x(93)90024-h

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  6 in total

1.  An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2.

Authors:  Andrzej Slominski; Igor Semak; Jacobo Wortsman; Jordan Zjawiony; Wei Li; Blazej Zbytek; Robert C Tuckey
Journal:  FEBS J       Date:  2006-07       Impact factor: 5.542

Review 2.  Review of progress in sterol oxidations: 1987-1995.

Authors:  L L Smith
Journal:  Lipids       Date:  1996-05       Impact factor: 1.880

3.  Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes.

Authors:  Andrzej T Slominski; Tae-Kang Kim; Jianjun Chen; Minh N Nguyen; Wei Li; Charles R Yates; Trevor Sweatman; Zorica Janjetovic; Robert C Tuckey
Journal:  Int J Biochem Cell Biol       Date:  2012-08-02       Impact factor: 5.085

4.  The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism.

Authors:  B M Forman; B Ruan; J Chen; G J Schroepfer; R M Evans
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-30       Impact factor: 11.205

5.  Metabolism of vitamin d2 to 17,20,24-trihydroxyvitamin d2 by cytochrome p450scc (CYP11A1).

Authors:  Minh N Nguyen; Andrzej Slominski; Wei Li; Yun Rui Ng; Robert C Tuckey
Journal:  Drug Metab Dispos       Date:  2008-12-30       Impact factor: 3.922

6.  Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3.

Authors:  Robert C Tuckey; Zorica Janjetovic; Wei Li; Minh N Nguyen; Michal A Zmijewski; Jordan Zjawiony; Andrzej Slominski
Journal:  J Steroid Biochem Mol Biol       Date:  2008-10-21       Impact factor: 4.292
  6 in total

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