Literature DB >> 8356450

Identification of a structural glycoprotein of an RNA virus as a ribonuclease.

R Schneider1, G Unger, R Stark, E Schneider-Scherzer, H J Thiel.   

Abstract

One of the three structural glycoproteins of classical swine fever virus (CSFV) is E0, a disulfide-bonded homodimer that induces virus-neutralizing antibodies and occurs in a virion-bound as well as a secreted form. E0 was shown to be similar to a family of fungal and plant ribonucleases. Purified E0 from CSFV-infected cells was a potent ribonuclease specific for uridine and inhibitable by zinc ions.

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Year:  1993        PMID： 8356450     DOI： 10.1126/science.8356450

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  60 in total

1.  A cellular J-domain protein modulates polyprotein processing and cytopathogenicity of a pestivirus.

Authors:  G Rinck; C Birghan; T Harada; G Meyers; H J Thiel; N Tautz
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

2.  CRISPR/Cas9-Mediated Knockout of DNAJC14 Verifies This Chaperone as a Pivotal Host Factor for RNA Replication of Pestiviruses.

Authors:  O Isken; A Postel; B Bruhn; E Lattwein; P Becher; N Tautz
Journal:  J Virol       Date:  2019-02-19       Impact factor: 5.103

3.  Classical swine fever virus glycoprotein E rns is an endoribonuclease with an unusual base specificity.

Authors:  Yvonne Hausmann; Gleyder Roman-Sosa; Heinz-Jürgen Thiel; Till Rümenapf
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

4.  Classical swine fever virus diagnostics and vaccine production in insect cells.

Authors:  M M Hulst; R J Moormann
Journal:  Cytotechnology       Date:  1996-01       Impact factor: 2.058

5.  Mutations abrogating the RNase activity in glycoprotein E(rns) of the pestivirus classical swine fever virus lead to virus attenuation.

Authors:  G Meyers; A Saalmüller; M Büttner
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

6.  Classical swine fever virus E(rns) deletion mutants: trans-complementation and potential use as nontransmissible, modified, live-attenuated marker vaccines.

Authors:  M N Widjojoatmodjo; H G van Gennip; A Bouma; P A van Rijn; R J Moormann
Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

7.  The carboxy-terminal sequence of the pestivirus glycoprotein E(rns) represents an unusual type of membrane anchor.

Authors:  Christiane Fetzer; Birke Andrea Tews; Gregor Meyers
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

8.  Mutation of cysteine 171 of pestivirus E rns RNase prevents homodimer formation and leads to attenuation of classical swine fever virus.

Authors:  Birke Andrea Tews; Eva-Maria Schürmann; Gregor Meyers
Journal:  J Virol       Date:  2009-03-04       Impact factor: 5.103

9.  A structural model of pestivirus E(rns) based on disulfide bond connectivity and homology modeling reveals an extremely rare vicinal disulfide.

Authors:  J P M Langedijk; P A van Veelen; W M M Schaaper; A H de Ru; R H Meloen; M M Hulst
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

10.  Isolation and characterization of noncytopathic pestivirus mutants reveals a role for nonstructural protein NS4B in viral cytopathogenicity.

Authors:  L Qu; L K McMullan; C M Rice
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103
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