Literature DB >> 8354387

Determination of renal clearance of neopterin by a pharmacokinetic approach.

W Estelberger1, G Weiss, W Petek, B Paletta, H Wachter, G Reibnegger.   

Abstract

Pharmacokinetic modelling was used to determine the glomerular filtration rate and tubular secretion of neopterin, a marker for cellular immune activation. The method involves parameter identification employing the transient venous plasma concentration profiles of marker substances. By combined i.v. injection of neopterin and inulin which is excreted exclusively via glomerular filtration, neopterin was shown to be excreted in addition to glomerular filtration, by tubular secretion: clearance of inulin, 112 (S.D. 2.2) ml/liter; clearance of neopterin, 499 (S.D. 79.7) ml/min. A pilot experiment using in addition p-amino hippuric acid suggests that neopterin and p-amino hippuric acid may employ the same carrier system for tubular secretion.

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Year:  1993        PMID： 8354387     DOI： 10.1016/0014-5793(93)80182-t

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Neopterin/7,8-dihydroneopterin is elevated in Duchenne muscular dystrophy patients and protects mdx skeletal muscle function.

Authors:  Angus Lindsay; Alexandra Schmiechen; Christopher M Chamberlain; James M Ervasti; Dawn A Lowe
Journal:  Exp Physiol       Date:  2018-07       Impact factor: 2.969

2.  In vivo effects of HIV-1 exposure in the presence and absence of single-dose nevirapine on cellular plasma activation markers of infants born to HIV-1-seropositive mothers.

Authors:  Diana B Schramm; Louise Kuhn; Glenda E Gray; Caroline T Tiemessen
Journal:  J Acquir Immune Defic Syndr       Date:  2006-08-15       Impact factor: 3.731

3.  Pharmacokinetics, pharmacodynamics, and safety of peginterferon beta-1a in subjects with normal or impaired renal function.

Authors:  Xiao Hu; Ali Seddighzadeh; Scott Stecher; Ying Zhu; Jaya Goyal; Mark Matson; Thomas Marbury; William Smith; Ivan Nestorov; Serena Hung
Journal:  J Clin Pharmacol       Date:  2014-09-23       Impact factor: 3.126

4.  Macrophage Activation Marker Neopterin: A Candidate Biomarker for Treatment Response and Relapse in Visceral Leishmaniasis.

Authors:  Anke E Kip; Monique Wasunna; Fabiana Alves; Jan H M Schellens; Jos H Beijnen; Ahmed M Musa; Eltahir A G Khalil; Thomas P C Dorlo
Journal:  Front Cell Infect Microbiol       Date:  2018-06-01       Impact factor: 5.293

Review 5.  Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing?

Authors:  Steven P Gieseg; Gregory Baxter-Parker; Angus Lindsay
Journal:  Antioxidants (Basel)       Date:  2018-06-26

6.  Neopterin Predicts Disease Severity in Hospitalized Patients With COVID-19.

Authors:  Rosa Bellmann-Weiler; Lukas Lanser; Francesco Burkert; Stefanie Seiwald; Gernot Fritsche; Sophie Wildner; Andrea Schroll; Sabine Koppelstätter; Katharina Kurz; Andrea Griesmacher; Günter Weiss
Journal:  Open Forum Infect Dis       Date:  2020-11-03       Impact factor: 3.835
  6 in total

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