Literature DB >> 8353809

Cytogenetic and fluorescence in situ hybridization investigation of ring chromosomes characterizing a specific pathologic subgroup of adipose tissue tumors.

P Dal Cin1, P Kools, R Sciot, I De Wever, B Van Damme, W Van de Ven, H Van den Berghe.   

Abstract

Cytogenetic analysis of 184 adipose tissue tumors, 175 lipomas, and nine liposarcomas (LPS) showed the presence of a ring chromosome and/or a long marker chromosome in 10 cases with common histologic features such as atypical stromal cells with or without lipoblasts. In five of the cases, this appeared to be the sole cytogenetic abnormality. Fluorescence in situ hybridization (FISH) analysis with a microclone library specific for chromosome region 12q13-q15 showed extensive staining of the ring and long marker chromosomes, indicating that genetic sequences of this particular region of chromosome 12 are present in these marker chromosomes, most likely in an amplified form.

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Year:  1993        PMID： 8353809     DOI： 10.1016/0165-4608(93)90001-3

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  27 in total

1.  Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity.

Authors:  D Gisselsson; L Pettersson; M Höglund; M Heidenblad; L Gorunova; J Wiegant; F Mertens; P Dal Cin; F Mitelman; N Mandahl
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

2.  Clinicopathological features of atypical lipomatous tumors of the laryngopharynx.

Authors:  Huai-yin Shi; Li-xin Wei; Hong-tian Wang; Lu Sun
Journal:  J Zhejiang Univ Sci B       Date:  2010-12       Impact factor: 3.066

3.  Expression of HMGI-C and HMGI(Y) in ordinary lipoma and atypical lipomatous tumors: immunohistochemical reactivity correlates with karyotypic alterations.

Authors:  G Tallini; P Dal Cin; K J Rhoden; G Chiapetta; G Manfioletti; V Giancotti; A Fusco; H Van den Berghe; R Sciot
Journal:  Am J Pathol       Date:  1997-07       Impact factor: 4.307

Review 4.  Impact of rearrangements on function and position of chromosomes in the interphase nucleus and on human genetic disorders.

Authors:  M B Qumsiyeh
Journal:  Chromosome Res       Date:  1995-12       Impact factor: 5.239

5.  Specificity of TLS-CHOP rearrangement for classic myxoid/round cell liposarcoma: absence in predominantly myxoid well-differentiated liposarcomas.

Authors:  C R Antonescu; A Elahi; M Humphrey; M Y Lui; J H Healey; M F Brennan; J M Woodruff; S C Jhanwar; M Ladanyi
Journal:  J Mol Diagn       Date:  2000-08       Impact factor: 5.568

Review 6.  Gene translocations in musculoskeletal neoplasms.

Authors:  Balaji Krishnan; Gaurav Khanna; Denis Clohisy
Journal:  Clin Orthop Relat Res       Date:  2008-06-20       Impact factor: 4.176

7.  [liposarcoma. Aspects of pathomorphology--an analysis of 209 tumos].

Authors:  C Kuhnen; M Lehnhardt; H U Steinau; K-M Müller
Journal:  Chirurg       Date:  2004-12       Impact factor: 0.955

8.  Predicting dedifferentiation in liposarcoma: a proteomic approach.

Authors:  Colt M McClain; David B Friedman; Tahar Hajri; Cheryl M Coffin; Justin M M Cates
Journal:  Virchows Arch       Date:  2013-05-26       Impact factor: 4.064

9.  Expression levels of HMGA2 in adipocytic tumors correlate with morphologic and cytogenetic subgroups.

Authors:  Hammurabi Bartuma; Ioannis Panagopoulos; Anna Collin; Domenico Trombetta; Henryk A Domanski; Nils Mandahl; Fredrik Mertens
Journal:  Mol Cancer       Date:  2009-06-09       Impact factor: 27.401

10.  The landscape of somatic copy-number alteration across human cancers.

Authors:  Rameen Beroukhim; Craig H Mermel; Dale Porter; Guo Wei; Soumya Raychaudhuri; Jerry Donovan; Jordi Barretina; Jesse S Boehm; Jennifer Dobson; Mitsuyoshi Urashima; Kevin T Mc Henry; Reid M Pinchback; Azra H Ligon; Yoon-Jae Cho; Leila Haery; Heidi Greulich; Michael Reich; Wendy Winckler; Michael S Lawrence; Barbara A Weir; Kumiko E Tanaka; Derek Y Chiang; Adam J Bass; Alice Loo; Carter Hoffman; John Prensner; Ted Liefeld; Qing Gao; Derek Yecies; Sabina Signoretti; Elizabeth Maher; Frederic J Kaye; Hidefumi Sasaki; Joel E Tepper; Jonathan A Fletcher; Josep Tabernero; José Baselga; Ming-Sound Tsao; Francesca Demichelis; Mark A Rubin; Pasi A Janne; Mark J Daly; Carmelo Nucera; Ross L Levine; Benjamin L Ebert; Stacey Gabriel; Anil K Rustgi; Cristina R Antonescu; Marc Ladanyi; Anthony Letai; Levi A Garraway; Massimo Loda; David G Beer; Lawrence D True; Aikou Okamoto; Scott L Pomeroy; Samuel Singer; Todd R Golub; Eric S Lander; Gad Getz; William R Sellers; Matthew Meyerson
Journal:  Nature       Date:  2010-02-18       Impact factor: 49.962
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