Literature DB >> 8353410

Genetics of cancer predisposition and progression.

K Schwechheimer1, W K Cavenee.   

Abstract

The development of human cancer is a multistep process that entails a progressively more malignant phenotype through the evolution of cellular subsets with increasing numbers of genetic alterations. Here we review the molecular genetics of human cancer predisposition and progression and describe paradigmatic cancer types and cancer syndromes. We also briefly consider the future impact of molecular biology on cancer diagnosis and treatment.

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Mesh：

Year:  1993        PMID： 8353410     DOI： 10.1007/bf00180066

Source DB:  PubMed          Journal:  Clin Investig        ISSN： 0941-0198


  152 in total

1.  Detection of high incidence of K-ras oncogenes during human colon tumorigenesis.

Authors:  K Forrester; C Almoguera; K Han; W E Grizzle; M Perucho
Journal:  Nature       Date:  1987 May 28-Jun 3       Impact factor: 49.962

Review 2.  Viral oncogenes.

Authors:  J M Bishop
Journal:  Cell       Date:  1985-08       Impact factor: 41.582

Review 3.  The molecular genetics of cellular oncogenes.

Authors:  H E Varmus
Journal:  Annu Rev Genet       Date:  1984       Impact factor: 16.830

4.  Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5.

Authors:  A Koufos; P Grundy; K Morgan; K A Aleck; T Hadro; B C Lampkin; A Kalbakji; W K Cavenee
Journal:  Am J Hum Genet       Date:  1989-05       Impact factor: 11.025

5.  Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc.

Authors:  M Schwab; H E Varmus; J M Bishop; K H Grzeschik; S L Naylor; A Y Sakaguchi; G Brodeur; J Trent
Journal:  Nature       Date:  1984 Mar 15-21       Impact factor: 49.962

6.  Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.

Authors:  G M Brodeur; R C Seeger; M Schwab; H E Varmus; J M Bishop
Journal:  Science       Date:  1984-06-08       Impact factor: 47.728

7.  Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1.

Authors:  I A Drummond; S L Madden; P Rohwer-Nutter; G I Bell; V P Sukhatme; F J Rauscher
Journal:  Science       Date:  1992-07-31       Impact factor: 47.728

8.  Mutation and cancer: statistical study of retinoblastoma.

Authors:  A G Knudson
Journal:  Proc Natl Acad Sci U S A       Date:  1971-04       Impact factor: 11.205

9.  L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer.

Authors:  M M Nau; B J Brooks; J Battey; E Sausville; A F Gazdar; I R Kirsch; O W McBride; V Bertness; G F Hollis; J D Minna
Journal:  Nature       Date:  1985 Nov 7-13       Impact factor: 49.962

10.  Increased expression of mutant forms of p53 oncogene in primary lung cancer.

Authors:  R Iggo; K Gatter; J Bartek; D Lane; A L Harris
Journal:  Lancet       Date:  1990-03-24       Impact factor: 79.321
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  3 in total

Review 1.  Tumor suppressor genes in molecular medicine.

Authors:  F Hoppe-Seyler; K Butz
Journal:  Clin Investig       Date:  1994-08

2.  Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor.

Authors:  S Y Cheng; H J Huang; M Nagane; X D Ji; D Wang; C C Shih; W Arap; C M Huang; W K Cavenee
Journal:  Proc Natl Acad Sci U S A       Date:  1996-08-06       Impact factor: 11.205

Review 3.  Genetic counselling and testing for susceptibility to breast, ovarian and colon cancer: where are we today?

Authors:  D E Cole; S Gallinger; D R McCready; B Rosen; J Engel; D Malkin
Journal:  CMAJ       Date:  1996-01-15       Impact factor: 8.262
  3 in total

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