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Literature DB >> 8352961

Nuclear organization of pre-mRNA processing.

Abstract

Recent studies have suggested that small nuclear ribonucleoprotein particles (snRNPs), non-snRNP splicing factors, and several heterogeneous nuclear RNP proteins change their organization within the cell in response to transcriptional activity. Several of the RNA substrates with which these factors interact have been shown to localize in tracks that are associated with regions in which splicing factors are concentrated (nuclear speckles). It is now thought that pre-mRNA splicing may occur within these tracks.

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Year: 1993 PMID： 8352961 DOI： 10.1016/0955-0674(93)90009-f

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

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Cited

47 in total

1. A role for the GSG domain in localizing Sam68 to novel nuclear structures in cancer cell lines.

Authors: T Chen; F M Boisvert; D P Bazett-Jones; S Richard
Journal: Mol Biol Cell Date: 1999-09 Impact factor: 4.138

2. Nuclear pre-mRNA compartmentalization: trafficking of released transcripts to splicing factor reservoirs.

Authors: I Melcák; S Cermanová; K Jirsová; K Koberna; J Malínský; I Raska
Journal: Mol Biol Cell Date: 2000-02 Impact factor: 4.138

3. Functional characterization of nuclear localization signals in yeast Sm proteins.

Authors: R Bordonné
Journal: Mol Cell Biol Date: 2000-11 Impact factor: 4.272

4. FBI-1 can stimulate HIV-1 Tat activity and is targeted to a novel subnuclear domain that includes the Tat-P-TEFb-containing nuclear speckles.

Authors: P Shannon Pendergrast; Chen Wang; Nouria Hernandez; Sui Huang
Journal: Mol Biol Cell Date: 2002-03 Impact factor: 4.138

10. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif.

Authors: M T Bedford; R Reed; P Leder
Journal: Proc Natl Acad Sci U S A Date: 1998-09-01 Impact factor: 11.205

Nuclear organization of pre-mRNA processing.

1. A role for the GSG domain in localizing Sam68 to novel nuclear structures in cancer cell lines.

2. Nuclear pre-mRNA compartmentalization: trafficking of released transcripts to splicing factor reservoirs.

3. Functional characterization of nuclear localization signals in yeast Sm proteins.

4. FBI-1 can stimulate HIV-1 Tat activity and is targeted to a novel subnuclear domain that includes the Tat-P-TEFb-containing nuclear speckles.

5. A protein-domain microarray identifies novel protein-protein interactions.

Review 6. AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes.

Review 7. The Cajal body and histone locus body.

8. Subnuclear targeting of the RNA-binding motif protein RBM6 to splicing speckles and nascent transcripts.

9. Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43.

10. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif.