Literature DB >> 8352558

A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer.

X Fu1, P Le, R M Hoffman.   

Abstract

We report here the development of an orthotopic-transplant model of human patient breast cancer in nude mice. Histologically-intact patient breast tumor tissue was transplanted as intact tissue to the mammary fat pad of nude mice where the tumor tissue grew extensively and metastasized to the lung. This is the first orthotopic-transplant metastatic model of human breast cancer. The potential clinical and basic-science uses of the model are discussed.

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Year:  1993        PMID： 8352558

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  65 in total

1.  Optically imageable metastatic model of human breast cancer.

Authors:  Xiaoming Li; Jinwei Wang; Zili An; Meng Yang; Eugene Baranov; Ping Jiang; Fangxian Sun; A R Moossa; Robert M Hoffman
Journal:  Clin Exp Metastasis       Date:  2002       Impact factor: 5.150

2.  Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer.

Authors:  Kei Kawaguchi; Kentaro Miyake; Qinghong Han; Shukuan Li; Yuying Tan; Kentaro Igarashi; Thinzar M Lwin; Takashi Higuchi; Tasuku Kiyuna; Masuyo Miyake; Hiromichi Oshiro; Michael Bouvet; Michiaki Unno; Robert M Hoffman
Journal:  Cell Cycle       Date:  2018-05-21       Impact factor: 4.534

3.  Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention.

Authors:  Kei Kawaguchi; Qinghong Han; Shukuan Li; Yuying Tan; Kentaro Igarashi; Tasuku Kiyuna; Kentaro Miyake; Masuyo Miyake; Bartosz Chmielowski; Scott D Nelson; Tara A Russell; Sarah M Dry; Yunfeng Li; Arun S Singh; Mark A Eckardt; Michiaki Unno; Fritz C Eilber; Robert M Hoffman
Journal:  Cell Cycle       Date:  2018-03-19       Impact factor: 4.534

4.  Cervical Cancer Patient-Derived Orthotopic Xenograft (PDOX) Is Sensitive to Cisplatinum and Resistant to Nab-paclitaxel.

Authors:  Takashi Murakami; Takuya Murata; Kei Kawaguchi; Tasuku Kiyuna; Kentaro Igarashi; Ho Kyoung Hwang; Yukihiko Hiroshima; Chihiro Hozumi; Shin Komatsu; Takashi Kikuchi; Thinzar M Lwin; Jonathan C Delong; Kentaro Miyake; Yong Zhang; Kuniya Tanaka; Michael Bouvet; Itaru Endo; Robert M Hoffman
Journal:  Anticancer Res       Date:  2017-01       Impact factor: 2.480

5.  Locally Trapping the C-C Chemokine Receptor Type 7 by Gene Delivery Nanoparticle Inhibits Lymphatic Metastasis Prior to Tumor Resection.

Authors:  Sai An; Karthik Tiruthani; Ying Wang; Ligeng Xu; Mengying Hu; Jingjing Li; Wantong Song; Hongnan Jiang; Jirui Sun; Rihe Liu; Leaf Huang
Journal:  Small       Date:  2019-01-28       Impact factor: 13.281

6.  Combination of gemcitabine and docetaxel regresses both gastric leiomyosarcoma proliferation and invasion in an imageable patient-derived orthotopic xenograft (iPDOX) model.

Authors:  Kei Kawaguchi; Kentaro Igarashi; Takashi Murakami; Tasuku Kiyuna; Scott D Nelson; Sarah M Dry; Yunfeng Li; Tara A Russell; Arun S Singh; Bartosz Chmielowski; Michiaki Unno; Fritz C Eilber; Robert M Hoffman
Journal:  Cell Cycle       Date:  2017-04-20       Impact factor: 4.534

7.  Photoimmunotherapy Inhibits Tumor Recurrence After Surgical Resection on a Pancreatic Cancer Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model.

Authors:  Yukihiko Hiroshima; Ali Maawy; Yong Zhang; Miguel Garcia Guzman; Roger Heim; Lew Makings; George A Luiken; Hisataka Kobayashi; Kuniya Tanaka; Itaru Endo; Robert M Hoffman; Michael Bouvet
Journal:  Ann Surg Oncol       Date:  2015-04-17       Impact factor: 5.344

Review 8.  In vivo animal models for studying brain metastasis: value and limitations.

Authors:  Inderjit Daphu; Terje Sundstrøm; Sindre Horn; Peter C Huszthy; Simone P Niclou; Per Ø Sakariassen; Heike Immervoll; Hrvoje Miletic; Rolf Bjerkvig; Frits Thorsen
Journal:  Clin Exp Metastasis       Date:  2013-01-16       Impact factor: 5.150

9.  Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: decoy, trap and kill chemotherapy moves toward the clinic.

Authors:  Kentaro Igarashi; Kei Kawaguchi; Tasuku Kiyuna; Kentaro Miyake; Masuyo Miyake; Shukuan Li; Qinghong Han; Yuying Tan; Ming Zhao; Yunfeng Li; Scott D Nelson; Sarah M Dry; Arun S Singh; Irmina A Elliott; Tara A Russell; Mark A Eckardt; Norio Yamamoto; Katsuhiro Hayashi; Hiroaki Kimura; Shinji Miwa; Hiroyuki Tsuchiya; Fritz C Eilber; Robert M Hoffman
Journal:  Cell Cycle       Date:  2018-04-10       Impact factor: 4.534

10.  A reproducible brain tumour model established from human glioblastoma biopsies.

Authors:  Jian Wang; Hrvoje Miletic; Per Ø Sakariassen; Peter C Huszthy; Hege Jacobsen; Narve Brekkå; Xingang Li; Peng Zhao; Sverre Mørk; Martha Chekenya; Rolf Bjerkvig; Per Ø Enger
Journal:  BMC Cancer       Date:  2009-12-29       Impact factor: 4.430
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