Literature DB >> 8352242

Azidothymidine (AZT)-induced siderosis.

S Pollack1, J Weaver.   

Abstract

Azidothymidine (AZT) interferes with heme synthesis. This should upregulate the synthesis of transferrin receptors and increase the amount of iron taken up by the cell. We found a 50% increase in the iron content of liver and a 20% increase in the iron content of macrophages in AZT-treated mice.

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Year:  1993        PMID: 8352242     DOI: 10.1002/ajh.2830430314

Source DB:  PubMed          Journal:  Am J Hematol        ISSN: 0361-8609            Impact factor:   10.047


  2 in total

1.  Influence of new antiretrovirals on hematological toxicity in HIV-exposed uninfected infants.

Authors:  Núria Rovira; Antoni Noguera-Julian; Susana Rives; Rubén Berrueco; Rebeca Lahoz; Clàudia Fortuny
Journal:  Eur J Pediatr       Date:  2016-05-10       Impact factor: 3.183

2.  AZT-induced oxidative cardiovascular toxicity: attenuation by Mg-supplementation.

Authors:  I Tong Mak; Joanna J Chmielinska; Jay H Kramer; William B Weglicki
Journal:  Cardiovasc Toxicol       Date:  2009-05-12       Impact factor: 3.231

  2 in total

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