M E Weinblatt1, A L Maier, J S Coblyn. 1. Department of Rheumatology and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Abstract
OBJECTIVE: To determine if simultaneously administered low dose leucovorin interferes with the efficacy of methotrexate (MTX). METHODS: An 8-week double blind placebo controlled study of leucovorin (1 mg) in 16 patients with rheumatoid arthritis receiving chronic MTX was performed at a single academic center. RESULTS: A flare of disease activity was not observed. Clinical variables of arthritis activity did not change in the leucovorin treated population. CONCLUSIONS: Low dose leucovorin when taken simultaneously with MTX did not interfere with the efficacy of MTX in a short term 8 week trial.
RCT Entities:
OBJECTIVE: To determine if simultaneously administered low dose leucovorin interferes with the efficacy of methotrexate (MTX). METHODS: An 8-week double blind placebo controlled study of leucovorin (1 mg) in 16 patients with rheumatoid arthritis receiving chronic MTX was performed at a single academic center. RESULTS: A flare of disease activity was not observed. Clinical variables of arthritis activity did not change in the leucovorin treated population. CONCLUSIONS: Low dose leucovorin when taken simultaneously with MTX did not interfere with the efficacy of MTX in a short term 8 week trial.
Authors: C J Haagsma; H J Blom; P L van Riel; M A van't Hof; B A Giesendorf; D van Oppenraaij-Emmerzaal; L B van de Putte Journal: Ann Rheum Dis Date: 1999-02 Impact factor: 19.103
Authors: M Hoekstra; A E van Ede; C J Haagsma; M A F J van de Laar; T W J Huizinga; M W M Kruijsen; R F J M Laan Journal: Ann Rheum Dis Date: 2003-05 Impact factor: 19.103
Authors: Emilio G Quetglas; Zlatan Mujagic; Simone Wigge; Daniel Keszthelyi; Sebastian Wachten; Ad Masclee; Walter Reinisch Journal: World J Gastroenterol Date: 2015-11-28 Impact factor: 5.742