| Literature DB >> 8349951 |
L Bondesson1, K Nordlind, S Lidén, E Sundström.
Abstract
The effect of serotonin and the serotonin antagonists ketanserin, methiotepine and ICS-205-930 on the migration of leucocytes was studied by using the sealed capillary migration technique. The migration of mononuclear leucocytes was inhibited by serotonin at 10(-4) and 10(-6)-10(-10)mol/l. An inhibition of the mononuclear leucocyte migration was also caused by ICS-205-930 at 10(-4)mol/l, ketanserin at 10(-4) and 10(-8)-10(-10)mol/l and methiotepine at 10(-4) and 10(-6)-10(-8)mol/l. No inhibiting effects of serotonin or the serotonin antagonists were found on the migration of polymorphonuclear leucocytes. Thus, both serotonin and serotonin antagonists may inhibit mononuclear leucocyte migration.Entities:
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Year: 1993 PMID： 8349951 DOI： 10.3109/08923979309025997
Source DB: PubMed Journal: Immunopharmacol Immunotoxicol ISSN： 0892-3973 Impact factor: 2.730