Literature DB >> 8349436

A phase II trial of deoxyspergualin in recurrent squamous cell head and neck cancer.

D G Pfister1, D Bajorin, R J Motzer, H Scher, C Louison, L Harrison, J Shah, E Strong, G Bosl.   

Abstract

Fifteen patients with recurrent squamous cell head and neck cancer were treated with deoxyspergualin. There were no objective responses in 14 evaluable patients. The most common toxicity was reversible hypotension, which prompted dose reduction in nine patients. Deoxyspergualin is not recommended for the treatment of squamous cell head and neck cancer.

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Year:  1993        PMID： 8349436     DOI： 10.1007/bf00873911

Source DB:  PubMed          Journal:  Invest New Drugs        ISSN： 0167-6997            Impact factor:   3.850


  5 in total

1.  Clinical pharmacology of deoxyspergualin in patients with advanced cancer.

Authors:  J F Muindi; S J Lee; L Baltzer; A Jakubowski; H I Scher; L A Sprancmanis; C M Riley; D Vander Velde; C W Young
Journal:  Cancer Res       Date:  1991-06-15       Impact factor: 12.701

2.  A new antitumor antibiotic, spergualin: isolation and antitumor activity.

Authors:  T Takeuchi; H Iinuma; S Kunimoto; T Masuda; M Ishizuka; M Takeuchi; M Hamada; H Naganawa; S Kondo; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1981-12       Impact factor: 2.649

Review 3.  Systemic therapy of head and neck cancer: most effective agents, areas of promise.

Authors:  S G Urba; A A Forastiere
Journal:  Oncology (Williston Park)       Date:  1989-04       Impact factor: 2.990

4.  Reporting results of cancer treatment.

Authors:  A B Miller; B Hoogstraten; M Staquet; A Winkler
Journal:  Cancer       Date:  1981-01-01       Impact factor: 6.860

5.  Inhibition of antibody response to Pseudomonas exotoxin and an immunotoxin containing Pseudomonas exotoxin by 15-deoxyspergualin in mice.

Authors:  L H Pai; D J FitzGerald; M Tepper; B Schacter; G Spitalny; I Pastan
Journal:  Cancer Res       Date:  1990-12-15       Impact factor: 13.312
  5 in total

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