Literature DB >> 8349096

The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces.

J M Ward1, J E Hodgson.   

Abstract

The cosmid cloning vector pHC79 has been used to clone fragments of chromosomal DNA from the Streptomyces: S. clavuligerus, S. jumonjinensis and S. katsurahamanus. These strains all produce both the beta-lactam antibiotic, cephamycin and the beta-lactamase inhibitor, clavulanic acid. Although structurally related these two beta-lactams are known to be derived from different biosynthetic precursors. Hybridisation studies and restriction mapping have shown that the gene clusters encoding the two biosynthetic pathways are chromosomally adjacent in these strains, thus creating a 'super-cluster' of genes involved in both the production and enhancement of activity of a beta-lactam antibiotic.

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Year:  1993        PMID： 8349096     DOI： 10.1111/j.1574-6968.1993.tb06326.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  47 in total

1.  Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus.

Authors:  S E Jensen; K J Elder; K A Aidoo; A S Paradkar
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

2.  Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerus.

Authors:  R H Mosher; A S Paradkar; C Anders; B Barton; S E Jensen
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

3.  The bla gene of the cephamycin cluster of Streptomyces clavuligerus encodes a class A beta-lactamase of low enzymatic activity.

Authors:  F Pérez-Llarena; J F Martín; M Galleni; J J Coque; J L Fuente; J M Frère; P Liras
Journal:  J Bacteriol       Date:  1997-10       Impact factor: 3.490

4.  A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production.

Authors:  Ju Yeon Song; Eun Sook Kim; Dae Wi Kim; Susan E Jensen; Kye Joon Lee
Journal:  J Ind Microbiol Biotechnol       Date:  2008-11-15       Impact factor: 3.346

5.  Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus.

Authors:  Bo Li; Christopher T Walsh
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-01       Impact factor: 11.205

6.  Mining bacterial genomes to reveal secret synergy.

Authors:  Mohammad Alanjary; Marnix H Medema
Journal:  J Biol Chem       Date:  2018-12-28       Impact factor: 5.157

7.  Applications of gene replacement technology to Streptomyces clavuligerus strain development for clavulanic acid production.

Authors:  A S Paradkar; R H Mosher; C Anders; A Griffin; J Griffin; C Hughes; P Greaves; B Barton; S E Jensen
Journal:  Appl Environ Microbiol       Date:  2001-05       Impact factor: 4.792

Review 8.  Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species.

Authors:  Gregory L Challis; David A Hopwood
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-11       Impact factor: 11.205

Review 9.  Directed evolution and rational approaches to improving Streptomyces clavuligerus deacetoxycephalosporin C synthase for cephalosporin production.

Authors:  Kian-Sim Goo; Chun-Song Chua; Tiow-Suan Sim
Journal:  J Ind Microbiol Biotechnol       Date:  2009-03-07       Impact factor: 3.346

Review 10.  Antibiotics from microbes: converging to kill.

Authors:  Michael A Fischbach
Journal:  Curr Opin Microbiol       Date:  2009-08-18       Impact factor: 7.934
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