| Literature DB >> 8348959 |
V del Marmol1, S Ito, I Jackson, J Vachtenheim, P Berr, G Ghanem, R Morandini, K Wakamatsu, G Huez.
Abstract
We have investigated the relationship in human cultured normal and malignant melanocytes between the accumulation of mRNAs encoding tyrosinase and tyrosinase-related protein-1 (TRP-1), the activity of tyrosinase and the presence of melanin. Tyrosinase mRNA correlates with tyrosinase activity and with the presence of pheomelanin, eumelanin or both melanin types. In contrast TRP-1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP-1 in the eumelanin synthesis pathway.Entities:
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Year: 1993 PMID: 8348959 DOI: 10.1016/0014-5793(93)81010-w
Source DB: PubMed Journal: FEBS Lett ISSN: 0014-5793 Impact factor: 4.124