R F Harrison1. 1. Royal College of Surgeons, Dublin, Ireland.
Abstract
OBJECTIVE: To compare the effect of hCG therapy with placebo or bed rest in women with threatened abortion. DESIGN: Random assignment, double-blind. SETTING: Community hospitals. PATIENTS AND INTERVENTIONS:Sixty-one women with viable pregnancies under 8 weeks' gestation on admission to hospital were randomly allocated to receive injections of hCG or placebo, or were advised to rest in bed. MAIN OUTCOME MEASURES: Abortion vs. continuation of pregnancy at 16 weeks' gestation. RESULTS:Thirty-one aborted: 6/20 on hCG, 10/21 on placebo, 15/20 on bed rest. hCG vs. bed rest, P < .01; placebo vs. bed rest, hCG vs. placebo--not significant. Plasma progesterone: continuing pregnancy > abortion, P < .01; continued with hCG vs. aborted on placebo, P < .001; continued with hCG vs. aborted with bed rest, P < .001. No significant differences in pregnancy/birth complications or infants' birth weight. Female/male ratio was 2:1. CONCLUSIONS:hCG is significantly better than bed rest.
RCT Entities:
OBJECTIVE: To compare the effect of hCG therapy with placebo or bed rest in women with threatened abortion. DESIGN: Random assignment, double-blind. SETTING: Community hospitals. PATIENTS AND INTERVENTIONS: Sixty-one women with viable pregnancies under 8 weeks' gestation on admission to hospital were randomly allocated to receive injections of hCG or placebo, or were advised to rest in bed. MAIN OUTCOME MEASURES: Abortion vs. continuation of pregnancy at 16 weeks' gestation. RESULTS: Thirty-one aborted: 6/20 on hCG, 10/21 on placebo, 15/20 on bed rest. hCG vs. bed rest, P < .01; placebo vs. bed rest, hCG vs. placebo--not significant. Plasma progesterone: continuing pregnancy > abortion, P < .01; continued with hCG vs. aborted on placebo, P < .001; continued with hCG vs. aborted with bed rest, P < .001. No significant differences in pregnancy/birth complications or infants' birth weight. Female/male ratio was 2:1. CONCLUSIONS:hCG is significantly better than bed rest.
Authors: Diana Man Ka Chan; Ka Wang Cheung; Sofie Shuk Fei Yung; Vivian Chi Yan Lee; Raymond Hang Wun Li; Ernest Hung Yu Ng Journal: Trials Date: 2016-08-17 Impact factor: 2.279