Literature DB >> 8347939

Bacterial adherence and epithelial cell cytokine production.

C Svanborg1, W Agace, S Hedges, H Linder, M Svensson.   

Abstract

Epithelial cell lines produce the cytokines IL-1 alpha, IL-6 and IL-8 when stimulated with Escherichia coli. The cytokine response is enhanced by P fimbriae. The epithelial cell lines also respond to stimulation with other cytokines. These in vitro findings were confirmed in vivo in patients with E. coli infection who secreted IL-6 and IL-8 into the urine. The observations suggest that epithelial cells play a more active role in the mucosal immune response than previously recognized.

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Year:  1993        PMID： 8347939

Source DB:  PubMed          Journal:  Zentralbl Bakteriol        ISSN： 0934-8840


  9 in total

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2.  Attachment of a noninvasive enteric pathogen, enteropathogenic Escherichia coli, to cultured human intestinal epithelial monolayers induces transmigration of neutrophils.

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Review 3.  Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis.

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4.  Distinct proinflammatory host responses to Neisseria gonorrhoeae infection in immortalized human cervical and vaginal epithelial cells.

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5.  Bacterial cell shape-dependent inflammatory response in mammary epithelial cells.

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6.  Uroepithelial cells are part of a mucosal cytokine network.

Authors:  S Hedges; W Agace; M Svensson; A C Sjögren; M Ceska; C Svanborg
Journal:  Infect Immun       Date:  1994-06       Impact factor: 3.441

7.  Induction of cytokines in phagocytic mammalian cells infected with virulent and avirulent Listeria strains.

Authors:  M Kuhn; W Goebel
Journal:  Infect Immun       Date:  1994-02       Impact factor: 3.441

8.  High-throughput identification of chemical inhibitors of E. coli Group 2 capsule biogenesis as anti-virulence agents.

Authors:  Carlos C Goller; Patrick C Seed
Journal:  PLoS One       Date:  2010-07-19       Impact factor: 3.240

9.  Lifting the mask: identification of new small molecule inhibitors of uropathogenic Escherichia coli group 2 capsule biogenesis.

Authors:  Carlos C Goller; Mehreen Arshad; James W Noah; Subramaniam Ananthan; Carrie W Evans; N Miranda Nebane; Lynn Rasmussen; Melinda Sosa; Nichole A Tower; E Lucile White; Benjamin Neuenswander; Patrick Porubsky; Brooks E Maki; Steven A Rogers; Frank Schoenen; Patrick C Seed
Journal:  PLoS One       Date:  2014-07-01       Impact factor: 3.240
  9 in total

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