Literature DB >> 8346682

Para-aminobenzoate synthase gene of Saccharomyces cerevisiae encodes a bifunctional enzyme.

J C Edman1, A L Goldstein, J G Erbe.   

Abstract

The Saccharomyces cerevisiae gene for para-aminobenzoate (PABA) synthase has been identified based upon its ability to confer sulfonamide resistance when present on a multicopy episomal vector. The 3840 bp DNA sequence fragment reported here contains a 2199 bp open reading frame encoding a 733 amino acid protein with similarity to the two components of PABA synthase described for prokaryotes (Escherichia coli PabA and PabB), suggesting that PABA synthase is bifunctional in yeast. The cloned sequence was confirmed to be PABA synthase by gene disruption. Chromosome gel analysis places the gene for PABA synthase on chromosome XIV.

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Year:  1993        PMID： 8346682     DOI： 10.1002/yea.320090613

Source DB:  PubMed          Journal:  Yeast        ISSN： 0749-503X            Impact factor:   3.239


  13 in total

1.  Los1p, involved in yeast pre-tRNA splicing, positively regulates members of the SOL gene family.

Authors:  W C Shen; D R Stanford; A K Hopper
Journal:  Genetics       Date:  1996-06       Impact factor: 4.562

2.  para-Aminobenzoic acid is a precursor in coenzyme Q6 biosynthesis in Saccharomyces cerevisiae.

Authors:  Beth Marbois; Letian X Xie; Samuel Choi; Kathleen Hirano; Kyle Hyman; Catherine F Clarke
Journal:  J Biol Chem       Date:  2010-06-30       Impact factor: 5.157

3.  Virulence studies of Aspergillus nidulans mutants requiring lysine or p-aminobenzoic acid in invasive pulmonary aspergillosis.

Authors:  C M Tang; J M Smith; H N Arst; D W Holden
Journal:  Infect Immun       Date:  1994-12       Impact factor: 3.441

4.  A chemogenomic screening of sulfanilamide-hypersensitive Saccharomyces cerevisiae mutants uncovers ABZ2, the gene encoding a fungal aminodeoxychorismate lyase.

Authors:  Javier Botet; Laura Mateos; José L Revuelta; María A Santos
Journal:  Eukaryot Cell       Date:  2007-09-14

5.  Structure and catalytic mechanism of yeast 4-amino-4-deoxychorismate lyase.

Authors:  Ya-Nan Dai; Chang-Biao Chi; Kang Zhou; Wang Cheng; Yong-Liang Jiang; Yan-Min Ren; Ke Ruan; Yuxing Chen; Cong-Zhao Zhou
Journal:  J Biol Chem       Date:  2013-07-01       Impact factor: 5.157

6.  Folate synthesis in plants: purification, kinetic properties, and inhibition of aminodeoxychorismate synthase.

Authors:  Tobias Sahr; Stéphane Ravanel; Gilles Basset; Brian P Nichols; Andrew D Hanson; Fabrice Rébeillé
Journal:  Biochem J       Date:  2006-05-15       Impact factor: 3.857

7.  Folate synthesis in plants: the p-aminobenzoate branch is initiated by a bifunctional PabA-PabB protein that is targeted to plastids.

Authors:  Gilles J C Basset; Eoin P Quinlivan; Stéphane Ravanel; Fabrice Rébeillé; Brian P Nichols; Kazuo Shinozaki; Motoaki Seki; Lori C Adams-Phillips; James J Giovannoni; Jesse F Gregory; Andrew D Hanson
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-26       Impact factor: 11.205

8.  Defining intermediates and redundancies in coenzyme Q precursor biosynthesis.

Authors:  Kyle P Robinson; Adam Jochem; Sheila E Johnson; Thiruchelvi R Reddy; Jason D Russell; Joshua J Coon; David J Pagliarini
Journal:  J Biol Chem       Date:  2021-04-14       Impact factor: 5.157

Review 9.  Folates in Plants: Research Advances and Progress in Crop Biofortification.

Authors:  Vera Gorelova; Lars Ambach; Fabrice Rébeillé; Christophe Stove; Dominique Van Der Straeten
Journal:  Front Chem       Date:  2017-03-29       Impact factor: 5.221

10.  Yeast chromosome III: new gene functions.

Authors:  E V Koonin; P Bork; C Sander
Journal:  EMBO J       Date:  1994-02-01       Impact factor: 11.598
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