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Literature DB >> 8344940

The gene encoding IFP 53/tryptophanyl-tRNA synthetase is regulated by the gamma-interferon activation factor.

I Strehlow¹, D Seegert, C Frick, F C Bange, C Schindler, E C Böttger, T Decker.

Abstract

We have obtained genomic DNA encoding the interferon-gamma (IFN-gamma)-inducible IFP 53/tryptophanyl-tRNA synthetase. Comparison with several different IFP 53 cDNA clones revealed a complex pattern of alternatively spliced 5'-untranslated regions. The interferon-responsive region within the IFP 53 promoter was found to contain a gamma-interferon activation site (GAS) but not the interferon-stimulated response element and to bind the gamma-interferon activation factor (GAF). GAF.GAS complexes contained the IFN-regulated 91-kDa protein. Competition experiments defined the GAS boundaries and showed that GAF binding to the IFP 53 GAS could be prevented by an excess of the IFN-gamma response regions of several other IFN-gamma-inducible genes. We thus provide evidence for a central role of GAS.GAF in gene transcription mediated by IFN-gamma and suggest a consensus sequence defining more precisely the requirements for GAF binding to DNA.

Entities: Gene

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Year: 1993 PMID： 8344940

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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Cited

13 in total

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Journal: EMBO J Date: 2001-01-15 Impact factor: 11.598

4. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland.

Authors: P Seshaiah; D J Andrew
Journal: Mol Biol Cell Date: 1999-05 Impact factor: 4.138

5. Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons.

Authors: A Meinke; F Barahmand-Pour; S Wöhrl; D Stoiber; T Decker
Journal: Mol Cell Biol Date: 1996-12 Impact factor: 4.272

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7. A factor induced by differentiation signals in cells of the macrophage lineage binds to the gamma interferon activation site.

Authors: A Eilers; M Baccarini; F Horn; R A Hipskind; C Schindler; T Decker
Journal: Mol Cell Biol Date: 1994-02 Impact factor: 4.272