Infectious complications during autotransplantation.

Bacterial and fungal infections are the most common cause of morbidity and mortality following autologous marrow transplant. An understanding of defects in host defense and the sources of bacterial and fungal infections allows a rational approach to controlling infections through prophylactic and empiric treatment. Recent availability of growth factors, broad-spectrum antibiotics, monoclonal antibodies to endotoxin, new antiviral agents, and new antifungal agents have enhanced our ability to successfully support patients through high-dose therapy and autologous stem cell reinfusion.