PURPOSE: To examine the sites of cone sensitivity loss in patients with retinitis pigmentosa by comparing focal electroretinographic and psychophysical modulation thresholds. METHODS: Both psychophysical and electrophysiologic increment threshold curves were obtained in retinitis pigmentosa patients and a group of age-matched, normally-sighted adults. RESULTS: The majority of the retinitis pigmentosa data could be accounted for by a vertical displacement of the normal curve. The retinitis pigmentosa patients showed similar patterns of cone sensitivity losses using both techniques. CONCLUSIONS: The combined electrophysiologic and psychophysical results provide support for an outer retina locus for these cone sensitivity losses. The data suggest that these deficits may be caused by a spatially independent loss of cone photoreceptors with normal adaptation properties in the remaining photoreceptors.
PURPOSE: To examine the sites of cone sensitivity loss in patients with retinitis pigmentosa by comparing focal electroretinographic and psychophysical modulation thresholds. METHODS: Both psychophysical and electrophysiologic increment threshold curves were obtained in retinitis pigmentosapatients and a group of age-matched, normally-sighted adults. RESULTS: The majority of the retinitis pigmentosa data could be accounted for by a vertical displacement of the normal curve. The retinitis pigmentosapatients showed similar patterns of cone sensitivity losses using both techniques. CONCLUSIONS: The combined electrophysiologic and psychophysical results provide support for an outer retina locus for these cone sensitivity losses. The data suggest that these deficits may be caused by a spatially independent loss of cone photoreceptors with normal adaptation properties in the remaining photoreceptors.
Authors: Enzo Maria Vingolo; Paolo Giuseppe Limoli; Robert Davis Jr Steigerwalt; Sandra Cinzia Carlesimo; Serena Salvatore Journal: Int Ophthalmol Date: 2019-08-28 Impact factor: 2.031
Authors: M Piccardi; D Marangoni; A M Minnella; M C Savastano; P Valentini; L Ambrosio; E Capoluongo; R Maccarone; S Bisti; B Falsini Journal: Evid Based Complement Alternat Med Date: 2012-07-18 Impact factor: 2.629
Authors: Judith S Schreiber; H Kenneth Hudnell; Andrew M Geller; Dennis E House; Kenneth M Aldous; Michael S Force; Karyn Langguth; Elizabeth J Prohonic; Jean C Parker Journal: Environ Health Perspect Date: 2002-07 Impact factor: 9.031