Literature DB >> 8344529

A Bacillus subtilis large ORF coding for a polypeptide highly similar to polyketide synthases.

C Scotti1, M Piatti, A Cuzzoni, P Perani, A Tognoni, G Grandi, A Galizzi, A M Albertini.   

Abstract

The nucleotide (nt) sequence of 13.6 kb of the outG locus of Bacillus subtilis, which maps at approximately 155 degrees between the genetic markers nrdA and polC, was determined. One putative coding sequence was identified corresponding to a large polypeptide of 4427 amino acids (aa). Structural organization at the nt and aa sequence level and extensive similarities of the deduced product, especially to EryA, suggest that the locus is potentially responsible for the synthesis of a polyketide molecule. The locus has been renamed pksX. Comparison of the deduced product with known fatty acid and polyketide synthases (PKS) suggested the presence of beta-ketosynthase, dehydratase, beta-ketoreductase and acyl-carrier protein domains. Preliminary data obtained with deletion mutants indicate that pksX is not an essential gene.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8344529     DOI： 10.1016/0378-1119(93)90347-6

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  11 in total

1.  Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approach.

Authors:  Leendert W Hamoen; Wiep Klaas Smits; Anne de Jong; Siger Holsappel; Oscar P Kuipers
Journal:  Nucleic Acids Res       Date:  2002-12-15       Impact factor: 16.971

2.  Molecular and biochemical characterization of the protein template controlling biosynthesis of the lipopeptide lichenysin.

Authors:  D Konz; S Doekel; M A Marahiel
Journal:  J Bacteriol       Date:  1999-01       Impact factor: 3.490

Review 3.  The nonribosomal peptide biosynthetic system--on the origins of structural diversity of peptides, cyclopeptides and related compounds.

Authors:  H Kleinkauf; H von Döhren
Journal:  Antonie Van Leeuwenhoek       Date:  1995       Impact factor: 2.271

4.  DNA microarray analysis of Bacillus subtilis DegU, ComA and PhoP regulons: an approach to comprehensive analysis of B.subtilis two-component regulatory systems.

Authors:  M Ogura; H Yamaguchi; Y Fujita; T Tanaka
Journal:  Nucleic Acids Res       Date:  2001-09-15       Impact factor: 16.971

5.  Promoter architecture in the flagellar regulon of Bacillus subtilis: high-level expression of flagellin by the sigma D RNA polymerase requires an upstream promoter element.

Authors:  K Fredrick; T Caramori; Y F Chen; A Galizzi; J D Helmann
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

6.  The yersiniabactin biosynthetic gene cluster of Yersinia enterocolitica: organization and siderophore-dependent regulation.

Authors:  C Pelludat; A Rakin; C A Jacobi; S Schubert; J Heesemann
Journal:  J Bacteriol       Date:  1998-02       Impact factor: 3.490

7.  Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42.

Authors:  Xiao-Hua Chen; Joachim Vater; Jörn Piel; Peter Franke; Romy Scholz; Kathrin Schneider; Alexandra Koumoutsi; Gabriele Hitzeroth; Nicolas Grammel; Axel W Strittmatter; Gerhard Gottschalk; Roderich D Süssmuth; Rainer Borriss
Journal:  J Bacteriol       Date:  2006-06       Impact factor: 3.490

8.  A nonessential signal peptidase II (Lsp) of Myxococcus xanthus might be involved in biosynthesis of the polyketide antibiotic TA.

Authors:  Y Paitan; E Orr; E Z Ron; E Rosenberg
Journal:  J Bacteriol       Date:  1999-09       Impact factor: 3.490

9.  Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase.

Authors:  J H Yu; T J Leonard
Journal:  J Bacteriol       Date:  1995-08       Impact factor: 3.490

10.  The Aspergillus parasiticus polyketide synthase gene pksA, a homolog of Aspergillus nidulans wA, is required for aflatoxin B1 biosynthesis.

Authors:  P K Chang; J W Cary; J Yu; D Bhatnagar; T E Cleveland
Journal:  Mol Gen Genet       Date:  1995-08-21
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.