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Literature DB >> 8343957

Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine.

X Cheng¹, S Kumar, J Posfai, J W Pflugrath, R J Roberts.

Abstract

The first three-dimensional structure of a DNA methyltransferase is presented. The crystal structure of the DNA (cytosine-5)-methyltransferase, M.HhaI (recognition sequence: GCGC), complexed with S-adenosyl-L-methionine has been determined and refined at 2.5 A resolution. The core of the structure is dominated by sequence motifs conserved among all DNA (cytosine-5)-methyltransferases, and these are responsible for cofactor binding and methyltransferase function.

Entities: Chemical

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Year: 1993 PMID： 8343957 DOI： 10.1016/0092-8674(93)90421-l

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

123 in total

1. Conserved plant genes with similarity to mammalian de novo DNA methyltransferases.

Authors: X Cao; N M Springer; M G Muszynski; R L Phillips; S Kaeppler; S E Jacobsen
Journal: Proc Natl Acad Sci U S A Date: 2000-04-25 Impact factor: 11.205

2. Strong minor groove base conservation in sequence logos implies DNA distortion or base flipping during replication and transcription initiation.

Authors: T D Schneider
Journal: Nucleic Acids Res Date: 2001-12-01 Impact factor: 16.971

Review 3. AdoMet-dependent methylation, DNA methyltransferases and base flipping.

Authors: X Cheng; R J Roberts
Journal: Nucleic Acids Res Date: 2001-09-15 Impact factor: 16.971

Review 4. Plant DNA methyltransferases.

Authors: E J Finnegan; K A Kovac
Journal: Plant Mol Biol Date: 2000-06 Impact factor: 4.076

5. Expression of ZmMET1, a gene encoding a DNA methyltransferase from maize, is associated not only with DNA replication in actively proliferating cells, but also with altered DNA methylation status in cold-stressed quiescent cells.

Authors: N Steward; T Kusano; H Sano
Journal: Nucleic Acids Res Date: 2000-09-01 Impact factor: 16.971

10. Cloning of CviPII nicking and modification system from chlorella virus NYs-1 and application of Nt.CviPII in random DNA amplification.

Authors: Siu-hong Chan; Zhenyu Zhu; James L Van Etten; Shuang-yong Xu
Journal: Nucleic Acids Res Date: 2004-11-29 Impact factor: 16.971

Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine.

1. Conserved plant genes with similarity to mammalian de novo DNA methyltransferases.

2. Strong minor groove base conservation in sequence logos implies DNA distortion or base flipping during replication and transcription initiation.

Review 3. AdoMet-dependent methylation, DNA methyltransferases and base flipping.

Review 4. Plant DNA methyltransferases.

5. Expression of ZmMET1, a gene encoding a DNA methyltransferase from maize, is associated not only with DNA replication in actively proliferating cells, but also with altered DNA methylation status in cold-stressed quiescent cells.

6. Autographa californica nucleopolyhedrovirus orf69 encodes an RNA cap (nucleoside-2'-O)-methyltransferase.

7. Control of catalytic cycle by a pair of analogous tRNA modification enzymes.

8. Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1).

9. Identification of DNA-binding proteins using structural, electrostatic and evolutionary features.

10. Cloning of CviPII nicking and modification system from chlorella virus NYs-1 and application of Nt.CviPII in random DNA amplification.