| Literature DB >> 8343528 |
S Potuznik1, D Gelvan, P Burda, P Saltman.
Abstract
The beta subunit of human hemoglobin can be oxidized site-specifically through beta-Cys-93 by Cu(II)(His)2. A series of thiol ligands, gold thiols and zinc(II) inhibit this oxidation. The thiol inhibitors formed a transient ternary intermediate involving Cu(I) with consequent inhibition of electron transfer from the Fe(II)-heme. The intermediate led to the formation of a disulfide at the beta-Cys-93 site. The most effective thiols achieved maximum inhibition at one equivalent per beta heme. Gold thiols and zinc complexes inhibited heme oxidation by competing with the Cu(II)(His)2 for the beta-Cys-93 site.Entities:
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Year: 1993 PMID： 8343528 DOI： 10.1016/0167-4838(93)90261-o
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002