Literature DB >> 8343500

DNA photolyase repairs the trans-syn cyclobutane thymine dimer.

S T Kim1, K Malhotra, C A Smith, J S Taylor, A Sancar.   

Abstract

DNA photolyases catalyze the splitting of the cyclobutane ring joining the two dihydropyrimidines of a pyrimidine dimer by a photoinduced electron-transfer reaction. Previous studies concluded that photolyase repairs only the cis-syn form of the eight stereoisomers of the cyclobutane pyrimidine dimer (Pyr[ ]Pyr). In this study we found that Escherichia coli photolyase binds to the trans-syn-I isomer of T[ ]T with about 10(4)-fold lower affinity than the cis-syn isomer but it repairs it relatively efficiently.

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Year:  1993        PMID： 8343500     DOI： 10.1021/bi00079a001

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  2 in total

1.  Mapping frequencies of endogenous oxidative damage and the kinetic response to oxidative stress in a region of rat mtDNA.

Authors:  W J Driggers; G P Holmquist; S P LeDoux; G L Wilson
Journal:  Nucleic Acids Res       Date:  1997-11-01       Impact factor: 16.971

2.  Photosensitized [2 + 2] cycloaddition of N-acetylated cytosine affords stereoselective formation of cyclobutane pyrimidine dimer.

Authors:  Junpei Yamamoto; Kosuke Nishiguchi; Koichiro Manabe; Chikahide Masutani; Fumio Hanaoka; Shigenori Iwai
Journal:  Nucleic Acids Res       Date:  2010-09-29       Impact factor: 16.971
  2 in total

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