Literature DB >> 834317

Specific effect of haloperidol on dopamine turnover in the frontal cortex.

P Laduron, K de Bie, J Leysen.   

Abstract

A single injection of haloperidol (0.08 mg/kg) produced marked increases in HVA in rabbit brain. Of the dopamine-containing areas studied, the elevation of HVA was significantly greater in the frontal cortex than in the striatum, the tuberculum olfactorium or the parietal cortex. After chronic treatment, a tolerance phenomenon to the effects of haloperidol on HVA was observed only in the striatal and limbic areas. The present results suggest that the frontal cortex may be a preferential target for the antipsychotic activity of neuroleptic agents.

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Year:  1977        PMID： 834317     DOI： 10.1007/BF00508472

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  13 in total

1.  Dopamine metabolism in the mesolimbic and mesocortical dopaminergic systems after single or repeated administrations of neuroleptics.

Authors:  B Scatton; J Glowinski; L Julou
Journal:  Brain Res       Date:  1976-06-04       Impact factor: 3.252

Review 2.  Dopamine receptors in the brain.

Authors:  L L Iversen
Journal:  Science       Date:  1975-06-13       Impact factor: 47.728

Review 3.  Pharmacology and biochemistry of haloperidol.

Authors:  C J Niemegeers; P M Laduron
Journal:  Proc R Soc Med       Date:  1976

4.  EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN.

Authors:  A CARLSSON; M LINDQVIST
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1963

5.  Differential distribution of opiate and neuroleptic receptors and dopamine-sensitive adenylate cyclase in rat brain.

Authors:  J Leysen; P Laduron
Journal:  Life Sci       Date:  1977-01-15       Impact factor: 5.037

6.  Dopamine turnover in the corpus striatum and the lumbic system after treatment with neuroleptic and anti-acetylcholine drugs.

Authors:  N E Andén
Journal:  J Pharm Pharmacol       Date:  1972-11       Impact factor: 3.765

7.  Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor".

Authors:  J W Kebabian; G L Petzold; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1972-08       Impact factor: 11.205

8.  Effect of single and repeated administration of clozapine on the metabolism of dopamine and noradrenaline in the brain of the rat.

Authors:  H R Bürki; W Ruch; H Asper; M Baggiolini; G Stille
Journal:  Eur J Pharmacol       Date:  1974-07       Impact factor: 4.432

9.  Dopamine receptor binding: differentiation of agonist and antagonist states with 3H-dopamine and 3H-haloperidol.

Authors:  I Creese; D R Burt; S H Snyder
Journal:  Life Sci       Date:  1975-09-15       Impact factor: 5.037

10.  Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.

Authors:  J Glowinski; L L Iversen
Journal:  J Neurochem       Date:  1966-08       Impact factor: 5.372
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  10 in total

1.  Functional antagonism between dopamine and noradrenaline within the caudate nucleus of cats: a phenomenon of rhythmically changing susceptibility.

Authors:  A R Cools; P A van Dongen; H J Janssen; A A Megens
Journal:  Psychopharmacology (Berl)       Date:  1978-12-08       Impact factor: 4.530

2.  Postnatal iron-induced motor behaviour alterations following chronic neuroleptic administration in mice.

Authors:  A Fredriksson; P Eriksson; T Archer
Journal:  J Neural Transm (Vienna)       Date:  2005-08-05       Impact factor: 3.575

3.  Functional consequences of iron overload in catecholaminergic interactions: the Youdim factor.

Authors:  Trevor Archer; Anders Fredriksson
Journal:  Neurochem Res       Date:  2007-08-12       Impact factor: 3.996

4.  Dose-response curves of homovanillic acid in pre-frontal cortex and caudate following antipsychotic drugs: relation to clinical potencies.

Authors:  W H Chang; T Y Chen; H S Wu; W H Hu; E K Yeh
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

5.  Evidence for a dopaminergic dominance in the 4,alpha-dimethyl-m-tyramine-induced hypermotility in mice.

Authors:  C Rüdeberg
Journal:  Psychopharmacology (Berl)       Date:  1978-12-08       Impact factor: 4.530

6.  Time-response curves of homovanillic acid in caudate and pre-frontal cortex following acute neuroleptic administration.

Authors:  W H Chang; T Y Chen; E K Yeh
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

Review 7.  A controlled study of Tourette syndrome. VII. Summary: a common genetic disorder causing disinhibition of the limbic system.

Authors:  D E Comings
Journal:  Am J Hum Genet       Date:  1987-11       Impact factor: 11.025

8.  Homovanillic acid in caudate and pre-frontal cortex following acute and chronic neuroleptic administration.

Authors:  M B Bowers; F J Hoffman
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

9.  Tolerance to fluphenazine and supersensitivity to apomorphine in central dopaminergic systems after chronic fluphenazine decanoate treatment.

Authors:  S C Wheeler; R H Roth
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-06       Impact factor: 3.000

Review 10.  Catecholamines: role in health and disease.

Authors:  R Laverty
Journal:  Drugs       Date:  1978-11       Impact factor: 9.546
  10 in total

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