OBJECTIVE: We sought to clarify the familial relationship between the nonschizophrenic, nonaffective psychoses (schizoaffective disorder [SAD], schizophreniform disorder, delusional disorder, and atypical psychosis) and schizophrenia and affective illness (AI). DESIGN: A case-controlled epidemiologic family study using DSM-III-R criteria. RESULTS: Compared with relatives of unscreened controls, the risk of nonschizophrenic, nonaffective psychoses was significantly elevated in relatives of probands with schizophrenia, SAD, schizotypal personality disorder, and psychotic AI. No significant elevation in risk to these disorders was seen in relatives of probands with nonpsychotic AI. The risk for SAD alone was significantly increased in relatives of probands with psychotic or bipolar AI. CONCLUSIONS: The nonschizophrenic, nonaffective psychoses have a significant familial relationship with both schizophrenia and schizotypical personality disorder. Schizoaffective disorder, as defined by DSM-III-R, shares familial etiologic factors with at least some forms of AI.
OBJECTIVE: We sought to clarify the familial relationship between the nonschizophrenic, nonaffective psychoses (schizoaffective disorder [SAD], schizophreniform disorder, delusional disorder, and atypical psychosis) and schizophrenia and affective illness (AI). DESIGN: A case-controlled epidemiologic family study using DSM-III-R criteria. RESULTS: Compared with relatives of unscreened controls, the risk of nonschizophrenic, nonaffective psychoses was significantly elevated in relatives of probands with schizophrenia, SAD, schizotypal personality disorder, and psychotic AI. No significant elevation in risk to these disorders was seen in relatives of probands with nonpsychotic AI. The risk for SAD alone was significantly increased in relatives of probands with psychotic or bipolar AI. CONCLUSIONS: The nonschizophrenic, nonaffective psychoses have a significant familial relationship with both schizophrenia and schizotypical personality disorder. Schizoaffective disorder, as defined by DSM-III-R, shares familial etiologic factors with at least some forms of AI.
Authors: E Jönsson; S Brené; T Geijer; L Terenius; A Tylec; M L Persson; G Sedvall Journal: Eur Arch Psychiatry Clin Neurosci Date: 1996 Impact factor: 5.270
Authors: Nil Kaymaz; Lydia Krabbendam; Ron de Graaf; Willem Nolen; Margreet Ten Have; Jim van Os Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2006-07-03 Impact factor: 4.328
Authors: Verena Krause; Olga Krastoshevsky; Michael J Coleman; J Alexander Bodkin; Jan Lerbinger; Lenore Boling; Fred Johnson; Anne Gibbs; Jonathan O Cole; Zhuying Huang; Nancy R Mendell; Deborah L Levy Journal: Schizophr Res Date: 2009-11-26 Impact factor: 4.939