Literature DB >> 8342566

Phosphatidylserine in the outer leaflet of red blood cells from beta-thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes.

V Borenstain-Ben Yashar1, Y Barenholz, E Hy-Am, E A Rachmilewitz, A Eldor.   

Abstract

Investigation of red blood cells from beta-thalassemia patients by means of prothrombinase assay reveals phosphatidylserine in the outer leaflet of the plasma membrane. This might explain their elevated susceptibility to phagocytosis by macrophages and the chronic hypercoagulable state, frequent thrombotic events, and life-long platelet activation that are found in thalassemic patients.

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Year:  1993        PMID： 8342566     DOI： 10.1002/ajh.2830440114

Source DB:  PubMed          Journal:  Am J Hematol        ISSN： 0361-8609            Impact factor:   10.047


  25 in total

Review 1.  β-thalassemia intermedia: a clinical perspective.

Authors:  Khaled M Musallam; Ali T Taher; Eliezer A Rachmilewitz
Journal:  Cold Spring Harb Perspect Med       Date:  2012-07       Impact factor: 6.915

Review 2.  Thalassemia and Moyamoya syndrome: unfurling an intriguing association.

Authors:  Shambaditya Das; Souvik Dubey; Mrinal Acharya; Subhankar Chatterjee; Durjoy Lahiri; Goutam Das; Biman Kanti Ray; Markus Kraemer
Journal:  J Neurol       Date:  2019-08-17       Impact factor: 4.849

Review 3.  Hypercoagulability and thrombotic complications in hemolytic anemias.

Authors:  Kenneth I Ataga
Journal:  Haematologica       Date:  2009-11       Impact factor: 9.941

Review 4.  RhIG for the treatment of immune thrombocytopenia: consensus and controversy (CME).

Authors:  Jenny M Despotovic; Michele P Lambert; Jay H Herman; Terry B Gernsheimer; Keith R McCrae; Michael D Tarantino; James B Bussel
Journal:  Transfusion       Date:  2011-10-07       Impact factor: 3.157

5.  Laboratory tests for coagulation system monitoring in a patient with β-thalassemia.

Authors:  Elena A Seregina; Olga F Nikulina; Nina V Tsvetaeva; Maya N Rodionova; Irina V Gribkova; Elena B Orel; Anastasiya P Zapariy; Anatoliy V Erasov; Anna N Balandina; Natalya M Ananyeva; Fazoil I Ataullakhanov
Journal:  Int J Hematol       Date:  2014-03-09       Impact factor: 2.490

6.  Absence of JAK2V617F mutation in patients with beta-thalassemia major and thrombocytosis due to splenectomy.

Authors:  E Vlachaki; A Kalogeridis; N Neokleous; V Perifanis; F Klonizakis; E Ioannidou; I Klonizakis
Journal:  Mol Biol Rep       Date:  2011-12-28       Impact factor: 2.316

Review 7.  Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia.

Authors:  Viktoria Kuhn; Lukas Diederich; T C Stevenson Keller; Christian M Kramer; Wiebke Lückstädt; Christina Panknin; Tatsiana Suvorava; Brant E Isakson; Malte Kelm; Miriam M Cortese-Krott
Journal:  Antioxid Redox Signal       Date:  2017-01-18       Impact factor: 8.401

8.  In vivo platelet activation and hyperaggregation in hemoglobin E/beta-thalassemia: a consequence of splenectomy.

Authors:  Vichai Atichartakarn; Pantep Angchaisuksiri; Katcharin Aryurachai; Suporn Chuncharunee; Ammarin Thakkinstian
Journal:  Int J Hematol       Date:  2003-04       Impact factor: 2.490

9.  Elevated tricuspid regurgitant jet velocity in subgroups of thalassemia patients: insight into pathophysiology and the effect of splenectomy.

Authors:  Sylvia T Singer; Frans Kuypers; Jeffery Fineman; Ginny Gildengorin; Sandra Larkin; Nancy Sweeters; Howard Rosenfeld; Gregory Kurio; Annie Higa; Michael Jeng; James Huang; Elliott P Vichinsky
Journal:  Ann Hematol       Date:  2014-02-28       Impact factor: 3.673

Review 10.  HbE/β-Thalassemia and Oxidative Stress: The Key to Pathophysiological Mechanisms and Novel Therapeutics.

Authors:  Rhoda Elison Hirsch; Nathawut Sibmooh; Suthat Fucharoen; Joel M Friedman
Journal:  Antioxid Redox Signal       Date:  2016-11-28       Impact factor: 8.401
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