| Literature DB >> 8342321 |
C H Romero1, T Barrett, S A Evans, R P Kitching, P D Gershon, C Bostock, D N Black.
Abstract
A recombinant capripoxvirus has been constructed containing a full-length cDNA of the fusion protein gene of rinderpest virus. The gene was inserted in the thymidine kinase gene of the capripox genome under the control of the vaccinia virus major late promoter p11 together with the Escherichia coli gpt gene in the opposite orientation under the control of the vaccinia early/late promoter p7.5. A vaccine prepared from this recombinant virus protected cattle against clinical rinderpest after a lethal challenge with a virulent virus isolate. In addition, the vaccine protected the cattle against lumpy skin disease.Entities:
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Year: 1993 PMID： 8342321 DOI： 10.1016/0264-410x(93)90258-y
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641