R Klein1, S E Moss, B E Klein. 1. University of Wisconsin, Department of Ophthalmology, Madison 53792-3220.
Abstract
PURPOSE: To examine the relationship between gross proteinuria, measured at the initial examination, and the 4-year incidence of proliferative diabetic retinopathy (PDR) in a population-based study in Wisconsin. METHODS: Gross proteinuria was measured by reagent strip. Diabetic retinopathy was determined from stereoscopic fundus photographs in a masked fashion using the modified Airlie House classification scheme. RESULTS: In the younger-onset group taking insulin (n = 693), the relative risk of proliferative retinopathy developing in those with gross proteinuria at baseline was 2.32 (95% confidence interval [CI]: 1.40,3.83) compared with those without gross proteinuria. For the older-onset group taking insulin, the relative risk was 2.02 (95% CI: 0.91,4.44), and for those not taking insulin it was 1.13 (95% CI: 0.15,8.50). After controlling for other risk variables, the relationship was of borderline statistical significance (P = 0.052) in the younger-onset group with no or early nonproliferative retinopathy at baseline. CONCLUSION: These data suggest that gross proteinuria is a risk indicator for proliferative retinopathy in younger-onset patients with diabetes. These patients might benefit from having regular ophthalmologic evaluation.
PURPOSE: To examine the relationship between gross proteinuria, measured at the initial examination, and the 4-year incidence of proliferative diabetic retinopathy (PDR) in a population-based study in Wisconsin. METHODS: Gross proteinuria was measured by reagent strip. Diabetic retinopathy was determined from stereoscopic fundus photographs in a masked fashion using the modified Airlie House classification scheme. RESULTS: In the younger-onset group taking insulin (n = 693), the relative risk of proliferative retinopathy developing in those with gross proteinuria at baseline was 2.32 (95% confidence interval [CI]: 1.40,3.83) compared with those without gross proteinuria. For the older-onset group taking insulin, the relative risk was 2.02 (95% CI: 0.91,4.44), and for those not taking insulin it was 1.13 (95% CI: 0.15,8.50). After controlling for other risk variables, the relationship was of borderline statistical significance (P = 0.052) in the younger-onset group with no or early nonproliferative retinopathy at baseline. CONCLUSION: These data suggest that gross proteinuria is a risk indicator for proliferative retinopathy in younger-onset patients with diabetes. These patients might benefit from having regular ophthalmologic evaluation.
Authors: Ronald Klein; Emily K Marino; Lewis H Kuller; Joseph F Polak; Russell P Tracy; John S Gottdiener; Gregory L Burke; Larry D Hubbard; Robin Boineau Journal: Br J Ophthalmol Date: 2002-01 Impact factor: 4.638
Authors: Qiuhong Li; Amrisha Verma; Ping-Yang Han; Takahiko Nakagawa; Richard J Johnson; Maria B Grant; Martha Campbell-Thompson; Yagna P R Jarajapu; Bo Lei; William W Hauswirth Journal: Invest Ophthalmol Vis Sci Date: 2010-04-30 Impact factor: 4.799
Authors: T Aspelund; O Thornórisdóttir; E Olafsdottir; A Gudmundsdottir; A B Einarsdóttir; J Mehlsen; S Einarsson; O Pálsson; G Einarsson; T Bek; E Stefánsson Journal: Diabetologia Date: 2011-07-27 Impact factor: 10.122
Authors: Ronald Klein; Michael D Knudtson; Kristine E Lee; Ronald Gangnon; Barbara E K Klein Journal: Ophthalmology Date: 2009-01-22 Impact factor: 12.079
Authors: Sami H Alzahrani; Marwan A Bakarman; Saleh M Alqahtani; Maha S Alqahtani; Nadeem Shafique Butt; Emad M Salawati; Ahmad Alkatheri; Ahmad Azam Malik; Khaled Saad Journal: Ther Adv Endocrinol Metab Date: 2018-03-04 Impact factor: 3.565