| Literature DB >> 8340816 |
J S Andreose1, R Xu, T Lømo, M M Salpeter, G Fumagalli.
Abstract
The effect of electrical stimulation on the stability of junctional ACh receptors (AChR) on soleus muscles of Wistar rats was compared to that of denervation and reinnervation. Denervation causes the degradation rate of the slowly degrading AChRs (Rs) at the neuromuscular junction to accelerate and be replaced by rapidly degrading AChRs (Rr), while reinnervation restabilizes the accelerated Rs. Electrical stimulation initiated at the time of denervation prevented the acceleration of the Rs. It could not, however, reverse the effect of denervation if initiated after the AChRs became destabilized, nor could it slow the degradation rate of the Rr. We conclude that electrical stimulation of denervated muscle downregulates the expression of the Rr and prevents the destabilization of Rs.Entities:
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Year: 1993 PMID： 8340816 PMCID： PMC6576548
Source DB: PubMed Journal: J Neurosci ISSN： 0270-6474 Impact factor: 6.167