Literature DB >> 8340812

The myomodulin-related neuropeptides: characterization of a gene encoding a family of peptide cotransmitters in Aplysia.

M W Miller1, S Beushausen, A Vitek, S Stamm, I Kupfermann, J Brosius, K R Weiss.   

Abstract

The myomodulin-related peptides comprise a family of cotransmitters that modulate neuromuscular signaling in the feeding system of Aplysia. In this study, cDNA clones encoding a myomodulin precursor polypeptide were isolated and characterized. This precursor contains seven different myomodulin-related peptides, one of which, myomodulin A, is present in 10 contiguous copies. The sequence of a myomodulin genomic clone indicates that all of these myomodulin-related peptides are encoded on a single exon. The myomodulin gene is expressed in a tissue-specific manner and myomodulin mRNA is localized to specific neurons in the Aplysia CNS. The presence of multiple related neuropeptides can greatly increase the range and precision of signaling at synapses where they act as modulator cotransmitters.

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Year:  1993        PMID： 8340812      PMCID： PMC6576528     

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  10 in total

1.  The enterins: a novel family of neuropeptides isolated from the enteric nervous system and CNS of Aplysia.

Authors:  Y Furukawa; K Nakamaru; H Wakayama; Y Fujisawa; H Minakata; S Ohta; F Morishita; O Matsushima; L Li; E Romanova; J V Sweedler; J H Park; A Romero; E C Cropper; N C Dembrow; J Jing; K R Weiss; F S Vilim
Journal:  J Neurosci       Date:  2001-10-15       Impact factor: 6.167

2.  Peptide cotransmitter release from motorneuron B16 in aplysia californica: costorage, corelease, and functional implications.

Authors:  F S Vilim; E C Cropper; D A Price; I Kupfermann; K R Weiss
Journal:  J Neurosci       Date:  2000-03-01       Impact factor: 6.167

Review 3.  RNA in the axonal domain: a new dimension in neuronal functioning?

Authors:  J Van Minnen
Journal:  Histochem J       Date:  1994-05

4.  Functional redundancy of FMRFamide-related peptides at the Drosophila larval neuromuscular junction.

Authors:  R S Hewes; E C Snowdeal; M Saitoe; P H Taghert
Journal:  J Neurosci       Date:  1998-09-15       Impact factor: 6.167

5.  Cloning and characterization of Aplysia neutral endopeptidase, a metallo-endopeptidase involved in the extracellular metabolism of neuropeptides in Aplysia californica.

Authors:  J P Zappulla; L Wickham; W Bawab; X F Yang; M V Storozhuk; V F Castellucci; L DesGroseillers
Journal:  J Neurosci       Date:  1999-06-01       Impact factor: 6.167

6.  Feedforward compensation mediated by the central and peripheral actions of a single neuropeptide discovered using representational difference analysis.

Authors:  Jian Jing; Jonathan V Sweedler; Elizabeth C Cropper; Vera Alexeeva; Ji-Ho Park; Elena V Romanova; Fang Xie; Nikolai C Dembrow; Bjoern C Ludwar; Klaudiusz R Weiss; Ferdinand S Vilim
Journal:  J Neurosci       Date:  2010-12-08       Impact factor: 6.167

7.  Myomodulin gene of Lymnaea: structure, expression, and analysis of neuropeptides.

Authors:  E Kellett; S J Perry; N Santama; B M Worster; P R Benjamin; J F Burke
Journal:  J Neurosci       Date:  1996-08-15       Impact factor: 6.167

8.  Distinct mechanisms produce functionally complementary actions of neuropeptides that are structurally related but derived from different precursors.

Authors:  Ferdinand S Vilim; Kosei Sasaki; Jurgen Rybak; Vera Alexeeva; Elizabeth C Cropper; Jian Jing; Irina V Orekhova; Vladimir Brezina; David Price; Elena V Romanova; Stanislav S Rubakhin; Nathan Hatcher; Jonathan V Sweedler; Klaudiusz R Weiss
Journal:  J Neurosci       Date:  2010-01-06       Impact factor: 6.167

9.  Marked changes in neuropeptide expression accompany broadcast spawnings in the gastropod Haliotis asinina.

Authors:  Patrick S York; Scott F Cummins; Sandie M Degnan; Ben J Woodcroft; Bernard M Degnan
Journal:  Front Zool       Date:  2012-05-09       Impact factor: 3.172

10.  Identification and functional characterization of the first molluscan neuromedin U receptor in the slug, Deroceras reticulatum.

Authors:  Seung-Joon Ahn; Rory J Mc Donnell; Jacob A Corcoran; Ruth C Martin; Man-Yeon Choi
Journal:  Sci Rep       Date:  2020-12-18       Impact factor: 4.996
  10 in total

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