OBJECTIVE: To determine whether circadian activity rhythms were altered in pediatric patients with depression. Evidence was sought for a shift in the timing of the rhythm, blunting of circadian amplitude, or emergence of noncircadian periodicities. METHOD: Locomotor activity was quantified in 57 patients with major depressive mood disorders (mean age 12.4 years) and 16 normal controls (9.9 years). Activity was measured in 5-minute epochs during 72 hours using belt-worn electronic activity monitors. RESULTS: Patients with mood disorders displayed a 15% decrease in the amplitude of their circadian rhythm, and a 52% increase in the magnitude of their twice-daily (hemicircadian) rhythm. No significant difference emerged in the timing of the circadian rhythm. Depressed inpatients and outpatients displayed comparable disturbances, which were most marked in adolescents. CONCLUSIONS: Circadian activity rhythms were dysregulated in pediatric patients with major depression. These findings may have etiological and diagnostic significance.
OBJECTIVE: To determine whether circadian activity rhythms were altered in pediatric patients with depression. Evidence was sought for a shift in the timing of the rhythm, blunting of circadian amplitude, or emergence of noncircadian periodicities. METHOD: Locomotor activity was quantified in 57 patients with major depressive mood disorders (mean age 12.4 years) and 16 normal controls (9.9 years). Activity was measured in 5-minute epochs during 72 hours using belt-worn electronic activity monitors. RESULTS:Patients with mood disorders displayed a 15% decrease in the amplitude of their circadian rhythm, and a 52% increase in the magnitude of their twice-daily (hemicircadian) rhythm. No significant difference emerged in the timing of the circadian rhythm. Depressed inpatients and outpatients displayed comparable disturbances, which were most marked in adolescents. CONCLUSIONS: Circadian activity rhythms were dysregulated in pediatric patients with major depression. These findings may have etiological and diagnostic significance.
Authors: Melanie P Leussis; Nadja Freund; Heather C Brenhouse; Britta S Thompson; Susan L Andersen Journal: Dev Neurosci Date: 2012-07-06 Impact factor: 2.984
Authors: Maria Eugenia Mesquita; Maria Eliza Pupo Finazzi; Leandro Lourenção Duarte; Lee Fu-I; José Alberto Del-Porto; Luiz Menna-Barreto Journal: Prim Care Companion CNS Disord Date: 2012-06-14
Authors: Gianni L Faedda; Kyoko Ohashi; Mariely Hernandez; Cynthia E McGreenery; Marie C Grant; Argelinda Baroni; Ann Polcari; Martin H Teicher Journal: J Child Psychol Psychiatry Date: 2016-01-22 Impact factor: 8.982
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