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Literature DB >> 834022

The human peripheral lymphocyte--a model system for studying the combined effect of psoralen plus black light.

Abstract

The effect of psoralen plus long wavelength ultraviolet light (UVA) on 3H-thymidine uptake of PHA stimulated human lymphocytes was investigated. PHA induced lymphocyte transformation was inhibited by the combined action of psoralen and UVA irradiation in a dose related manner. Inhibition of DNA-synthesis occurred at concentrations of psoralen that can be expected in the serum of patients treated by systemic photochemotherapy. No effect was noted at these psoralen concentrations in the absence of UVA irradiation. Also did UVA irradiation in the absence of psoralen not inhibit 3H-thymidine incorporation into PHA stimulated lymphocytes.

Entities: Chemical Disease Species

Mesh：

Substances：
DNA
Methoxsalen

Year: 1977 PMID： 834022 DOI： 10.1007/BF01490241

Source DB: PubMed Journal: Klin Wochenschr ISSN： 0023-2173

10 in total

1. Lethal photosensitization of bacteria with 8-methoxypsoralen to long wave length ultraviolet radiation.

Authors: E L OGINSKY; G S GREEN; D G GRIFFITH; W L FOWLKS
Journal: J Bacteriol Date: 1959-12 Impact factor: 3.490

2. [Clinical experience with the 8-methoxypsoralen-UVA therapy (photochemotherapy) of psoriasis].

Authors: C Hofmann; G Plewig; O Braun-Falco
Journal: Hautarzt Date: 1976-12 Impact factor: 0.751

3. Preliminary report on the protection from Ehrlich ascites tumor with tumor cells photoinactivated in the presence of psoralen or 8-methyl-psoralen.

Authors: L Musajo; P A Visentini; F Baccichetti
Journal: Z Naturforsch B Date: 1970-06 Impact factor: 1.047

4. Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light.

Authors: J A Parrish; T B Fitzpatrick; L Tanenbaum; M A Pathak
Journal: N Engl J Med Date: 1974-12-05 Impact factor: 91.245

5. Psoralen plus black light inhibits epidermal DNA synthesis.

Authors: J F Walter; W H Kelsey; J J Voorhees; E A Duell
Journal: Arch Dermatol Date: 1973-06

6. Light-induced cross-linking of DNA in the presence of a furocoumarin (psoralen). Studies with phage lambda, Escherichia coli, and mouse leukemia cells.

Authors: R S Cole
Journal: Biochim Biophys Acta Date: 1970-09-17

7. DNA synthesis in normal and xeroderma pigmentosum fibroblasts following treatment with 8-methoxypsoralen and long wave ultraviolet light.

Authors: H P Baden; J M Parrington; J D Delhanty; M A Pathak
Journal: Biochim Biophys Acta Date: 1972-03-24

8. Evaluation of the phototoxic potential of topically applied agents using long-wave ultraviolet light.

Authors: C W Stott; J Stasse; R Bonomo; A H Campbell
Journal: J Invest Dermatol Date: 1970-11 Impact factor: 8.551

9. [Photochemotherapy of psoriasis: clinical experiences with 152 patients (author's transl)].

Authors: K Wolff; H Hönigsmann; F Gschnait; K Konrad
Journal: Dtsch Med Wochenschr Date: 1975-11-28 Impact factor: 0.628

10. Treatment of psoriasis with oral psoralens and longwave ultraviolet light. Therapeutic results and cytogenetic hazards.

Authors: G Swanbeck; M Thyresson-Hök; A Bredberg; B Lambert
Journal: Acta Derm Venereol Date: 1975 Impact factor: 4.437

10 in total

8 in total

The human peripheral lymphocyte--a model system for studying the combined effect of psoralen plus black light.

1. Lethal photosensitization of bacteria with 8-methoxypsoralen to long wave length ultraviolet radiation.

2. [Clinical experience with the 8-methoxypsoralen-UVA therapy (photochemotherapy) of psoriasis].

3. Preliminary report on the protection from Ehrlich ascites tumor with tumor cells photoinactivated in the presence of psoralen or 8-methyl-psoralen.

4. Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light.

5. Psoralen plus black light inhibits epidermal DNA synthesis.

6. Light-induced cross-linking of DNA in the presence of a furocoumarin (psoralen). Studies with phage lambda, Escherichia coli, and mouse leukemia cells.

7. DNA synthesis in normal and xeroderma pigmentosum fibroblasts following treatment with 8-methoxypsoralen and long wave ultraviolet light.

8. Evaluation of the phototoxic potential of topically applied agents using long-wave ultraviolet light.

9. [Photochemotherapy of psoriasis: clinical experiences with 152 patients (author's transl)].

10. Treatment of psoriasis with oral psoralens and longwave ultraviolet light. Therapeutic results and cytogenetic hazards.

1. [Effects of UV-C and of 8-MOP + UV-A on the T- and B-population of human lymphocytes in vitro (author's transl)].

2. [Semen analysis under photochemotherapy (PUVA-therapy) (author's transl)].

3. Professor Dr. Dr. h. c. Otto Braun-Falco.

4. PUVA-therapy for alopecia areata. An investigative study.

5. Photochemotherapy: a new promising chemical derivative.

6. Stimulation of lymphocytes in patients with psoriasis under photochemotherapy. A study of lymphocyte transformation.

7. Dark effect of 8-methoxypsoralen (8-MOP) on lymphocytes.

8. Lymphocyte proliferation during PUVA therapy.