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Literature DB >> 834020

Human mammary cancers in nu/nu-mice. A model for testing in research and clinic.

G Bastert, H Schmidt-Matthiesen, R T Michel, H P Fortmeyer, R Sturm, D Nord, R Gerner.

Abstract

37 (85%) of 44 human breast cancers are successfully transplanted on thymus-aplastic nu/nu-mice without adjunctive immunotherapy. 16 weeks after transplantation 4 rapidly growing tumours are showing human, female karyotypes. Subsequent investigations proved a good correlation between original tumour and transplant: histology, 3H-thymidine marking index and receptors of androgen and estorgen.

Entities: Disease Species

Mesh：

Year: 1977 PMID： 834020 DOI： 10.1007/BF01469088

Source DB: PubMed Journal: Klin Wochenschr ISSN： 0023-2173

8 in total

1. Characterization and assay of steroid hormone receptors and steroid-binding serum proteins by agargel electrophoresis at low temperature.

Authors: R K Wagner
Journal: Hoppe Seylers Z Physiol Chem Date: 1972-08

2. [Selective tumour chemotherapy using oncobiograms (author's transl)].

Authors: M Volm; M Kaufmann; K Wayss; K Goerttler; J Mattern
Journal: Dtsch Med Wochenschr Date: 1974-01-11 Impact factor: 0.628

Review 3. [Tissue culture and cancer chemotherapy].

Authors: S Tanneberger
Journal: Arch Geschwulstforsch Date: 1968

4. Heterotransplantation of a human malignant tumour to "Nude" mice.

Authors: J Rygaard; C O Povlsen
Journal: Acta Pathol Microbiol Scand Date: 1969

5. [The evaluation of the cyclophosphamide sensitivity of human tumours by determining the incorporation of tritiated uridine and thymidine into the nucleic acids of human tumor cells in vitro in presence of 4-hydroxycyclophosphamide (author's transl)].

Authors: G Bastert; H Schmidt-Matthiesen; G Voelcker; G Peter; H J Hohorst
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1975-09-22

6. [In-vitro testing of the sensitivity of mammary carcinoma cells to cytostatic drugs (author's transl)].

Authors: G Bastert; H Schmidt-Matthiesen; R Gerner; R T Michel; D Nord; G Leppien
Journal: Dtsch Med Wochenschr Date: 1975-10-03 Impact factor: 0.628

7. Heterotransplantation of human malignant tumors in "nude" thymusless mice. II. Malignant tumors induced by injection of cell cultures derived from human solid tumors.

Authors: B C Giovanella; J S Stehlin; L J Williams
Journal: J Natl Cancer Inst Date: 1974-03 Impact factor: 13.506

8. [In vitro assay for cyclophosphamide-sensitivity of human tumours: the effect of 4-hydro-peroxy-cyclophosphamide on the incorporation of 3H-uridine into the nucleic acids of human tumour cells (author's transl)].

Authors: G Bastert; G Voelcker; G Peter; H Schmidt-Matthiesen; H J Hohorst
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1976-03-19

8 in total

6 in total

Review 1. Predictive tests in cancer chemotherapy. A reappraisal.

Authors: R Osieka; S Seeber; C G Schmidt
Journal: Klin Wochenschr Date: 1984-03-01

2. Adjuvant chemotherapy of human colorectal adenocarcinoma after growth on mice with congenital thymic dysplasia ("nude"). 2. Tumor remission following treatment with 5-FU and VCR of xenotransplanted primary human colorectal adenocarcinomas.

Authors: R Schmitz; C A Schmitz; J Hüper; R Richlmayr
Journal: J Cancer Res Clin Oncol Date: 1980 Impact factor: 4.553

6. Characterization of two human mammary carcinomas, MT-1 and MT-3, suitable for in vivo testing of ether lipids and their derivatives.

Authors: H Naundorf; E C Rewasowa; I Fichtner; B Büttner; M Becker; M Görlich
Journal: Breast Cancer Res Treat Date: 1992 Impact factor: 4.624