| Literature DB >> 833869 |
M Daveau, J Pavie-Fischer, L Rivat, C Rivat, C Ropartz, H H Peter, J P Cesarini, F M Kourilsky.
Abstract
Three hundred and ninety-seven sera from 185 melanoma patients were studied. These sera were classified into three groups according to stage of disease. An alteration in the level of the IgG4 subclass was found. It was related to the dissemination of disease. The percentage of abnormalities (either increased or decreased levels of IgG4) was more frequent in patients with stage II and III diseases (55 and 53%, respectively) than in patients with stage I(19%). The higher frequencies of high titers of IgG4 were essentially detected in advanced disease. The biologic significance of the increase of IgG4 in melanoma remains obscure. The increase may be related to the development of facilitating antibodies of the IgG4 subclass.Entities:
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Year: 1977 PMID： 833869 DOI： 10.1093/jnci/58.2.189
Source DB: PubMed Journal: J Natl Cancer Inst ISSN： 0027-8874 Impact factor: 13.506