Literature DB >> 833817

An improved method for O-demethylation of codeine.

J A Lawson, J I DeGraw.   

Abstract

The O-demethylation of codeine was effected by sodium propylmercaptide in dimethylformamide at 125 degrees C to afford morphine in 80% yield. Similar treatment of thebaine was unrewarding.

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Year:  1977        PMID： 833817     DOI： 10.1021/jm00211a037

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  4 in total

1.  A One-Step Synthesis of β-Bromocodide from Codeine.

Authors:  Christopher W Cunningham; Jeffrey R Deschamps; Andrew Coop
Journal:  J Pharm Sci Pharmacol       Date:  2014-03

Review 2.  Diels-Alder Adducts of Morphinan-6,8-Dienes and Their Transformations.

Authors:  János Marton; Anikó Fekete; Paul Cumming; Sándor Hosztafi; Pál Mikecz; Gjermund Henriksen
Journal:  Molecules       Date:  2022-04-30       Impact factor: 4.927

3.  C-demethylation and 1, 2-amino shift in (E)-2-(1-(3-aminophenyl) ethylidene)hydrazinecarboxamide to (E)-2-(2-aminobenzylidene)hydrazinecarboxamide and their applications.

Authors:  M Sennappan; Sinosh Skariyachan; Praveen B Managutti; Shubha Shridhar Gunaga
Journal:  Sci Rep       Date:  2020-12-14       Impact factor: 4.379

4.  1,2-Carboboration of Arylallenes by In Situ Generated Alkenylboranes for the Synthesis of 1,4-Dienes.

Authors:  Arthur Averdunk; Max Hasenbeck; Tizian Müller; Jonathan Becker; Urs Gellrich
Journal:  Chemistry       Date:  2022-04-21       Impact factor: 5.020
  4 in total

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