Literature DB >> 833734

High-pressure liquid chromatographic analysis of drugs in biological fluids I. Warfarin.

T D Bjornsson, T F Blaschke, P J Meffin.   

Abstract

A rapid, sensitive, and specific high-pressure liquid chromatographic (HPLC) method for the quantitative analysis of warfarin in plasma is described. The method involves a single solvent extraction of warfarin and the internal standard form acidified plasma, followed by evaporation and HPLC analysis. The method is sufficiently sensitive and accurate for most pharmacokinetic studies: concentrations between 0.1 and 4.0 mug/ml can be measured with a coefficient of variation of 2-5%. Known metabolites of warfarin do not interfere with the analysis.

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Year:  1977        PMID： 833734     DOI： 10.1002/jps.2600660144

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  8 in total

1.  Interaction of clofibrate with warfarin. I. Effect of clofibrate on the disposition of the optical enantiomorphs of warfarin.

Authors:  T D Bjornsson; P J Meffin; T F Blaschke
Journal:  J Pharmacokinet Biopharm       Date:  1977-10

2.  Investigation of patients with abnormal response to warfarin.

Authors:  D P Bentley; G Backhouse; A Hutchings; R L Haddon; B Spragg; P A Routledge
Journal:  Br J Clin Pharmacol       Date:  1986-07       Impact factor: 4.335

3.  Oral cholestyramine increases elimination of warfarin after overdose.

Authors:  S Renowden; D Westmoreland; J P White; P A Routledge
Journal:  Br Med J (Clin Res Ed)       Date:  1985-08-24

4.  Aminoglutethimide and warfarin. A new important drug interaction.

Authors:  P E Lønning; S Kvinnsland; G Jahren
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

Review 5.  Pharmacokinetic optimisation of the treatment of deep vein thrombosis.

Authors:  A Iorio; G Agnelli
Journal:  Clin Pharmacokinet       Date:  1997-02       Impact factor: 6.447

6.  The effect of beta-adrenoceptor antagonists on the pharmacokinetics and pharmacodynamics of warfarin after a single dose.

Authors:  N D Bax; M S Lennard; G T Tucker; H F Woods; N R Porter; R G Malia; F E Preston
Journal:  Br J Clin Pharmacol       Date:  1984-05       Impact factor: 4.335

7.  Interaction of sulphinpyrazone with warfarin.

Authors:  J O Miners; T Foenander; S Wanwimolruk; A S Gallus; D J Birkett
Journal:  Eur J Clin Pharmacol       Date:  1982       Impact factor: 2.953

8.  Amiodarone reduces plasma warfarin clearance in man.

Authors:  A H Watt; M R Stephens; D C Buss; P A Routledge
Journal:  Br J Clin Pharmacol       Date:  1985-12       Impact factor: 4.335
  8 in total

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