Experimental foreign body infection in mice.

A number of experimental foreign body infections have been described. We present here an easy, reproducible staphylococcal foreign body infection model in mice. The failure of treatment with methicillin and gentamicin is demonstrated, while the usefulness of antibiotic prophylaxis is documented. The usual correlations between pharmacokinetic parameters and the effect of antibiotics in vivo seem not to hold when a foreign body is present. The model may be applicable to large-scale evaluation of different antibiotic regimens.